The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance
Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells. Regulatory T lymphocytes (Treg) and tolerogenic dendritic cells play essential roles in the establishment and persistence of...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/430394 |
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| _version_ | 1832565458012733440 |
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| author | Nona Janikashvili Bernard Bonnotte Emmanuel Katsanis Nicolas Larmonier |
| author_facet | Nona Janikashvili Bernard Bonnotte Emmanuel Katsanis Nicolas Larmonier |
| author_sort | Nona Janikashvili |
| collection | DOAJ |
| description | Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells. Regulatory T lymphocytes (Treg) and tolerogenic dendritic cells play essential roles in the establishment and persistence of cancer-induced immunosuppression. Differentiating dendritic cells (DCs) exposed to tumor-derived factors may be arrested at an immature stage becoming inept at initiating immune responses and may induce effector T-cell anergy or deletion. These tolerogenic DCs, which accumulate in patients with different types of cancers, are also involved in the generation of Treg. In turn, Treg that expand during tumor progression contribute to the immune tolerance of cancer by impeding DCs' ability to orchestrate immune responses and by directly inhibiting antitumoral T lymphocytes. Herein we review these bidirectional communications between DCs and Treg as they relate to the promotion of cancer-induced tolerance. |
| format | Article |
| id | doaj-art-89f728effe9d4fc08ec68e14503d15a6 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-89f728effe9d4fc08ec68e14503d15a62025-02-03T01:07:45ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/430394430394The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced ToleranceNona Janikashvili0Bernard Bonnotte1Emmanuel Katsanis2Nicolas Larmonier3Faculty of Medicine, INSERM UMR 866, IFR 100, 21000 Dijon, FranceFaculty of Medicine, INSERM UMR 866, IFR 100, 21000 Dijon, FranceDepartment of Pediatrics, Steele Children's Research Center, Department of Immunobiology, BIO5 Institute, and Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724-5073, USADepartment of Pediatrics, Steele Children's Research Center, Department of Immunobiology, BIO5 Institute, and Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724-5073, USATumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells. Regulatory T lymphocytes (Treg) and tolerogenic dendritic cells play essential roles in the establishment and persistence of cancer-induced immunosuppression. Differentiating dendritic cells (DCs) exposed to tumor-derived factors may be arrested at an immature stage becoming inept at initiating immune responses and may induce effector T-cell anergy or deletion. These tolerogenic DCs, which accumulate in patients with different types of cancers, are also involved in the generation of Treg. In turn, Treg that expand during tumor progression contribute to the immune tolerance of cancer by impeding DCs' ability to orchestrate immune responses and by directly inhibiting antitumoral T lymphocytes. Herein we review these bidirectional communications between DCs and Treg as they relate to the promotion of cancer-induced tolerance.http://dx.doi.org/10.1155/2011/430394 |
| spellingShingle | Nona Janikashvili Bernard Bonnotte Emmanuel Katsanis Nicolas Larmonier The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance Clinical and Developmental Immunology |
| title | The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance |
| title_full | The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance |
| title_fullStr | The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance |
| title_full_unstemmed | The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance |
| title_short | The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance |
| title_sort | dendritic cell regulatory t lymphocyte crosstalk contributes to tumor induced tolerance |
| url | http://dx.doi.org/10.1155/2011/430394 |
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