Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets
Pomegranate peel waste is a byproduct of juice processing and 1.6 million tons are produced globally each year. Pomegranate peels have a high dietary fiber content and unique polyphenol profile suggesting it may have health benefits. This study aimed to investigate the hypocholesterolemic and anti-o...
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Elsevier
2025-06-01
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| Series: | Food Hydrocolloids for Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025925000020 |
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| author | Xingzhu Wu Wallace Yokoyama Yuqing Tan Glenn Bartley Ling Chen James Pan Priscila Alves Buongiorno Jose Berrios Tara McHugh Zhongli Pan |
| author_facet | Xingzhu Wu Wallace Yokoyama Yuqing Tan Glenn Bartley Ling Chen James Pan Priscila Alves Buongiorno Jose Berrios Tara McHugh Zhongli Pan |
| author_sort | Xingzhu Wu |
| collection | DOAJ |
| description | Pomegranate peel waste is a byproduct of juice processing and 1.6 million tons are produced globally each year. Pomegranate peels have a high dietary fiber content and unique polyphenol profile suggesting it may have health benefits. This study aimed to investigate the hypocholesterolemic and anti-obesity effects of pomegranate peel powder (PPP) and water extract (PPE) in Golden Syrian hamsters fed with high-fat (39 % fat calorie, HF) diets. Hamsters were fed either the HF, or the HF diet supplemented with 2.5 % or 5 % PPE (LE and HE, respectively), or 5 % or 10 % PPP (low-peel (LP) and high-peel (HP), respectively. After 4 weeks of feeding, hamsters gained 16.10- 33.82 g of weight and the feeding efficacy ranged from 0.10 to 0.18. The HP group had the lowest weight gain and feed efficacy while others were not significantly different. The HP group had significantly lower liver-to-body weight ratio (3.10 ± 0.08 % vs 3.65 ± 0.09 %), fasting blood glucose (68.11 ± 5.27 vs 82.94 ± 6.49 mg/dL), and hepatic lipid content (6.31 ± 0.26 vs 7.49 ± 0.22 g/100 g liver) compared to the HF group. PPP ingestion significantly increased LDL but decreased triglycerides. PPP and PPE feeding resulted in microbiota phyla Firmicutes-to-Bacteroidetes ratio characteristic of leaner phenotypes. HMG-CoAR and LDLR expression were reduced, suggesting that decreased uptake of LDL was not sufficient to lower plasma LDL, even with reduced cholesterol synthesis. |
| format | Article |
| id | doaj-art-89efd450dcdc4569bdf62e7d29a244de |
| institution | Kabale University |
| issn | 2667-0259 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj-art-89efd450dcdc4569bdf62e7d29a244de2025-01-26T05:05:13ZengElsevierFood Hydrocolloids for Health2667-02592025-06-017100196Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american dietsXingzhu Wu0Wallace Yokoyama1Yuqing Tan2Glenn Bartley3Ling Chen4James Pan5Priscila Alves Buongiorno6Jose Berrios7Tara McHugh8Zhongli Pan9Department of Biological and Agricultural Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA; Corresponding author at: Address: 3022 Bainer Hall, University of California, Davis, California 95616, USA.Healthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USAHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USA; Beijing Higher Institution Engineering Research Center of Animal Product, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, ChinaHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USAHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USA; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, ChinaHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USAHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USAHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USAHealthy Processed Foods Research Unit, USDA-ARS-WRRC, 800 Buchanan St., Albany, CA 94710, USADepartment of Biological and Agricultural Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, USAPomegranate peel waste is a byproduct of juice processing and 1.6 million tons are produced globally each year. Pomegranate peels have a high dietary fiber content and unique polyphenol profile suggesting it may have health benefits. This study aimed to investigate the hypocholesterolemic and anti-obesity effects of pomegranate peel powder (PPP) and water extract (PPE) in Golden Syrian hamsters fed with high-fat (39 % fat calorie, HF) diets. Hamsters were fed either the HF, or the HF diet supplemented with 2.5 % or 5 % PPE (LE and HE, respectively), or 5 % or 10 % PPP (low-peel (LP) and high-peel (HP), respectively. After 4 weeks of feeding, hamsters gained 16.10- 33.82 g of weight and the feeding efficacy ranged from 0.10 to 0.18. The HP group had the lowest weight gain and feed efficacy while others were not significantly different. The HP group had significantly lower liver-to-body weight ratio (3.10 ± 0.08 % vs 3.65 ± 0.09 %), fasting blood glucose (68.11 ± 5.27 vs 82.94 ± 6.49 mg/dL), and hepatic lipid content (6.31 ± 0.26 vs 7.49 ± 0.22 g/100 g liver) compared to the HF group. PPP ingestion significantly increased LDL but decreased triglycerides. PPP and PPE feeding resulted in microbiota phyla Firmicutes-to-Bacteroidetes ratio characteristic of leaner phenotypes. HMG-CoAR and LDLR expression were reduced, suggesting that decreased uptake of LDL was not sufficient to lower plasma LDL, even with reduced cholesterol synthesis.http://www.sciencedirect.com/science/article/pii/S2667025925000020Fecal microbiotaLipid profile ameliorationPomegranate peelWeight controlWestern high-fat diet |
| spellingShingle | Xingzhu Wu Wallace Yokoyama Yuqing Tan Glenn Bartley Ling Chen James Pan Priscila Alves Buongiorno Jose Berrios Tara McHugh Zhongli Pan Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets Food Hydrocolloids for Health Fecal microbiota Lipid profile amelioration Pomegranate peel Weight control Western high-fat diet |
| title | Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets |
| title_full | Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets |
| title_fullStr | Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets |
| title_full_unstemmed | Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets |
| title_short | Pomegranate peel powder and extract improved weight control, lipid metabolism and gut microbiota in hamsters fed with standard american diets |
| title_sort | pomegranate peel powder and extract improved weight control lipid metabolism and gut microbiota in hamsters fed with standard american diets |
| topic | Fecal microbiota Lipid profile amelioration Pomegranate peel Weight control Western high-fat diet |
| url | http://www.sciencedirect.com/science/article/pii/S2667025925000020 |
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