Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy
Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called “microenvironments.” Among...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2023/1655750 |
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| author | Yi Li Yuang Zhang Yiqin Tao Xianpeng Huang Chao Yu Haibin Xu Jiangjie Chen Kaishun Xia Kesi Shi Yongxiang Zhang Jingkai Wang Jiawei Shu Feng Cheng Shaoke Wang Chengzhen Liang Fangcai Li Xiaopeng Zhou Qixin Chen |
| author_facet | Yi Li Yuang Zhang Yiqin Tao Xianpeng Huang Chao Yu Haibin Xu Jiangjie Chen Kaishun Xia Kesi Shi Yongxiang Zhang Jingkai Wang Jiawei Shu Feng Cheng Shaoke Wang Chengzhen Liang Fangcai Li Xiaopeng Zhou Qixin Chen |
| author_sort | Yi Li |
| collection | DOAJ |
| description | Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called “microenvironments.” Among the various factors in the microenvironment, the cell-surface glycan acts as a mediator of cell-matrix and cell-cell interactions and manipulates the behavior of cells. Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. By presenting unnatural glycans on the surface, MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses. In this review, we firstly focused on the determining role of glycans on cellular activity; then, we introduced how MGE influences glycosylation and subsequently affects cell fate; at last, we outlined the application of MGE in regenerative therapy, especially in the musculoskeletal system, and the future direction of MGE is discussed. |
| format | Article |
| id | doaj-art-89e8fbc708a541ffa094e79bd03df3fd |
| institution | DOAJ |
| issn | 1687-9678 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-89e8fbc708a541ffa094e79bd03df3fd2025-08-20T03:06:48ZengWileyStem Cells International1687-96782023-01-01202310.1155/2023/1655750Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative TherapyYi Li0Yuang Zhang1Yiqin Tao2Xianpeng Huang3Chao Yu4Haibin Xu5Jiangjie Chen6Kaishun Xia7Kesi Shi8Yongxiang Zhang9Jingkai Wang10Jiawei Shu11Feng Cheng12Shaoke Wang13Chengzhen Liang14Fangcai Li15Xiaopeng Zhou16Qixin Chen17Department of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryDepartment of Orthopedics SurgeryCell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called “microenvironments.” Among the various factors in the microenvironment, the cell-surface glycan acts as a mediator of cell-matrix and cell-cell interactions and manipulates the behavior of cells. Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. By presenting unnatural glycans on the surface, MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses. In this review, we firstly focused on the determining role of glycans on cellular activity; then, we introduced how MGE influences glycosylation and subsequently affects cell fate; at last, we outlined the application of MGE in regenerative therapy, especially in the musculoskeletal system, and the future direction of MGE is discussed.http://dx.doi.org/10.1155/2023/1655750 |
| spellingShingle | Yi Li Yuang Zhang Yiqin Tao Xianpeng Huang Chao Yu Haibin Xu Jiangjie Chen Kaishun Xia Kesi Shi Yongxiang Zhang Jingkai Wang Jiawei Shu Feng Cheng Shaoke Wang Chengzhen Liang Fangcai Li Xiaopeng Zhou Qixin Chen Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy Stem Cells International |
| title | Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy |
| title_full | Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy |
| title_fullStr | Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy |
| title_full_unstemmed | Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy |
| title_short | Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy |
| title_sort | metabolic glycoengineering a promising strategy to remodel microenvironments for regenerative therapy |
| url | http://dx.doi.org/10.1155/2023/1655750 |
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