Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma
Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/2180417 |
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| _version_ | 1832564550740738048 |
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| author | Zhiyong Dong Lingxin Xiong Weijie Zhang Peter G. Gibson Ting Wang Yanjiao Lu Guoqiang Wang Hui Li Fang Wang |
| author_facet | Zhiyong Dong Lingxin Xiong Weijie Zhang Peter G. Gibson Ting Wang Yanjiao Lu Guoqiang Wang Hui Li Fang Wang |
| author_sort | Zhiyong Dong |
| collection | DOAJ |
| description | Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a complex heterogenous disease caused by genetic and environmental factors. TLRs are the primary proteins associated with the innate and adaptive immune responses to these fatal factors and play an important role in recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which initiates the downstream immune response. Due to the complex TLRs cascade and nowadays unsuccessful control in asthma, new studies are focused on TLRs and other potential targets in TLR cascade to minimize airway inflammation. |
| format | Article |
| id | doaj-art-89e612ac217b4b9ba7f45aab340ab790 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-89e612ac217b4b9ba7f45aab340ab7902025-02-03T01:10:50ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/21804172180417Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in AsthmaZhiyong Dong0Lingxin Xiong1Weijie Zhang2Peter G. Gibson3Ting Wang4Yanjiao Lu5Guoqiang Wang6Hui Li7Fang Wang8Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, ChinaDepartment of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, ChinaDepartment of Respiratory Disease, Jilin Provincial People’s Hospital, Changchun 130021, ChinaDepartment of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW 2305, AustraliaDepartment of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, ChinaDepartment of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, ChinaDepartment of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, ChinaDepartment of Respiratory Disease, Jilin Provincial People’s Hospital, Changchun 130021, ChinaDepartment of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, ChinaInflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a complex heterogenous disease caused by genetic and environmental factors. TLRs are the primary proteins associated with the innate and adaptive immune responses to these fatal factors and play an important role in recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which initiates the downstream immune response. Due to the complex TLRs cascade and nowadays unsuccessful control in asthma, new studies are focused on TLRs and other potential targets in TLR cascade to minimize airway inflammation.http://dx.doi.org/10.1155/2016/2180417 |
| spellingShingle | Zhiyong Dong Lingxin Xiong Weijie Zhang Peter G. Gibson Ting Wang Yanjiao Lu Guoqiang Wang Hui Li Fang Wang Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma Mediators of Inflammation |
| title | Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma |
| title_full | Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma |
| title_fullStr | Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma |
| title_full_unstemmed | Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma |
| title_short | Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma |
| title_sort | holding the inflammatory system in check tlrs and their targeted therapy in asthma |
| url | http://dx.doi.org/10.1155/2016/2180417 |
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