Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens
Aims. Cardiovascular diseases are the primary cause of premature morbidity and mortality in early breast cancer patients after treatment with cardiotoxic chemotherapeutic agents. Arterial stiffness is an independent risk factor for future cardiovascular diseases and can be used as a predictive marke...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/5352914 |
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| _version_ | 1832562542365376512 |
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| author | Özlem Yersal Ufuk Eryilmaz Hakan Akdam Nezih Meydan Sabri Barutca |
| author_facet | Özlem Yersal Ufuk Eryilmaz Hakan Akdam Nezih Meydan Sabri Barutca |
| author_sort | Özlem Yersal |
| collection | DOAJ |
| description | Aims. Cardiovascular diseases are the primary cause of premature morbidity and mortality in early breast cancer patients after treatment with cardiotoxic chemotherapeutic agents. Arterial stiffness is an independent risk factor for future cardiovascular diseases and can be used as a predictive marker of subclinical cardiac damage. The aim of this study is to analyze the arterial stiffness in breast cancer patients who are in the follow-up period after receiving anthracycline-based chemotherapy regimens with trastuzumab. Methods and Material. We enrolled 45 HER2-positive breast cancer patients who are on follow-up at least for six months after completion of adjuvant chemotherapy with trastuzumab, and cardiovascular risk matched 30 control volunteers. The measurements were done with pulse wave analyzing machine. Results. Mean pulse wave velocity was higher in breast cancer patients compared to controls. The pulse wave velocity was significantly higher in patients receiving aromatase inhibitors compared to patients under tamoxifen. It was also significantly higher in postmenopausal breast cancer patients than postmenopausal controls. Conclusions. Arterial stiffness measurements may predict the breast cancer survivors with higher risk for cardiovascular events earlier in the follow-up period, and necessary preventive approaches and/or treatments can be applied. |
| format | Article |
| id | doaj-art-89e3c01e45aa43a890438dab2927a86d |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-89e3c01e45aa43a890438dab2927a86d2025-02-03T01:22:28ZengWileyCardiology Research and Practice2090-80162090-05972018-01-01201810.1155/2018/53529145352914Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based RegimensÖzlem Yersal0Ufuk Eryilmaz1Hakan Akdam2Nezih Meydan3Sabri Barutca4Oncology Department, Internal Medicine Department, Adnan Menderes University, Aydin, TurkeyCardiology Department, Adnan Menderes University, Aydin, TurkeyNephrology Department, Internal Medicine Department, Adnan Menderes University, Aydin, TurkeyOncology Department, Internal Medicine Department, Adnan Menderes University, Aydin, TurkeyOncology Department, Internal Medicine Department, Adnan Menderes University, Aydin, TurkeyAims. Cardiovascular diseases are the primary cause of premature morbidity and mortality in early breast cancer patients after treatment with cardiotoxic chemotherapeutic agents. Arterial stiffness is an independent risk factor for future cardiovascular diseases and can be used as a predictive marker of subclinical cardiac damage. The aim of this study is to analyze the arterial stiffness in breast cancer patients who are in the follow-up period after receiving anthracycline-based chemotherapy regimens with trastuzumab. Methods and Material. We enrolled 45 HER2-positive breast cancer patients who are on follow-up at least for six months after completion of adjuvant chemotherapy with trastuzumab, and cardiovascular risk matched 30 control volunteers. The measurements were done with pulse wave analyzing machine. Results. Mean pulse wave velocity was higher in breast cancer patients compared to controls. The pulse wave velocity was significantly higher in patients receiving aromatase inhibitors compared to patients under tamoxifen. It was also significantly higher in postmenopausal breast cancer patients than postmenopausal controls. Conclusions. Arterial stiffness measurements may predict the breast cancer survivors with higher risk for cardiovascular events earlier in the follow-up period, and necessary preventive approaches and/or treatments can be applied.http://dx.doi.org/10.1155/2018/5352914 |
| spellingShingle | Özlem Yersal Ufuk Eryilmaz Hakan Akdam Nezih Meydan Sabri Barutca Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens Cardiology Research and Practice |
| title | Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens |
| title_full | Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens |
| title_fullStr | Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens |
| title_full_unstemmed | Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens |
| title_short | Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens |
| title_sort | arterial stiffness in breast cancer patients treated with anthracycline and trastuzumab based regimens |
| url | http://dx.doi.org/10.1155/2018/5352914 |
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