Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient
A 59-year-old male with past medical history significant for non-Hodgkin’s lymphoma status after chemotherapy presented with acute onset of neck pain, odynophagia, and dysphagia associated with subjective fever, chills, and dyspnea. Physical findings included a temperature of 38.4°C, hypertension, a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/741041 |
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| author | Madiha M. Alvi David S. Meyer Nicholas J. Hardin James G. deKay Annis M. Marney Matthew P. Gilbert |
| author_facet | Madiha M. Alvi David S. Meyer Nicholas J. Hardin James G. deKay Annis M. Marney Matthew P. Gilbert |
| author_sort | Madiha M. Alvi |
| collection | DOAJ |
| description | A 59-year-old male with past medical history significant for non-Hodgkin’s lymphoma status after chemotherapy presented with acute onset of neck pain, odynophagia, and dysphagia associated with subjective fever, chills, and dyspnea. Physical findings included a temperature of 38.4°C, hypertension, and tachycardia. Patient was found to have anterior neck tenderness. Laboratory evaluation revealed neutropenia. The patient was started on empiric antibacterial and antiviral therapy and continued on home prophylactic antifungal treatment. Thyroid function tests revealed overt hyperthyroidism. A thyroid ultrasound showed heterogeneous echotexture without discrete nodules. Subacute thyroiditis was treated with methylprednisolone, metoprolol, and opiate analgesics. Patient’s antibacterial, antifungal, and antiviral treatments were broadened. A fine needle aspiration was not conducted. The patient’s condition deteriorated rapidly over his brief hospital course and he expired. Autopsy showed fungal thyroiditis secondary to disseminated invasive Aspergillus. This report describes the presentation of fungal thyroiditis secondary to disseminated invasive Aspergillus originating from the respiratory tract. The authors review the diagnostic challenges, pathophysiology, and treatment of this condition. |
| format | Article |
| id | doaj-art-89c648de96e04c178c211ab2d6d8844b |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-89c648de96e04c178c211ab2d6d8844b2025-02-03T05:59:49ZengWileyCase Reports in Endocrinology2090-65012090-651X2013-01-01201310.1155/2013/741041741041Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised PatientMadiha M. Alvi0David S. Meyer1Nicholas J. Hardin2James G. deKay3Annis M. Marney4Matthew P. Gilbert5Department of Medicine, Division of Endocrinology and Diabetes, The University of Vermont College of Medicine, Burlington, VT 05401, USADepartment of Medicine, The University of Vermont College of Medicine, Burlington, VT 05401, USADepartment of Pathology and Laboratory Medicine, The University of Vermont College of Medicine, Burlington, VT 05401, USADepartment of Pathology and Laboratory Medicine, The University of Vermont College of Medicine, Burlington, VT 05401, USADepartment of Medicine, Division of Endocrinology and Diabetes, The University of Vermont College of Medicine, Burlington, VT 05401, USADepartment of Medicine, Division of Endocrinology and Diabetes, The University of Vermont College of Medicine, Burlington, VT 05401, USAA 59-year-old male with past medical history significant for non-Hodgkin’s lymphoma status after chemotherapy presented with acute onset of neck pain, odynophagia, and dysphagia associated with subjective fever, chills, and dyspnea. Physical findings included a temperature of 38.4°C, hypertension, and tachycardia. Patient was found to have anterior neck tenderness. Laboratory evaluation revealed neutropenia. The patient was started on empiric antibacterial and antiviral therapy and continued on home prophylactic antifungal treatment. Thyroid function tests revealed overt hyperthyroidism. A thyroid ultrasound showed heterogeneous echotexture without discrete nodules. Subacute thyroiditis was treated with methylprednisolone, metoprolol, and opiate analgesics. Patient’s antibacterial, antifungal, and antiviral treatments were broadened. A fine needle aspiration was not conducted. The patient’s condition deteriorated rapidly over his brief hospital course and he expired. Autopsy showed fungal thyroiditis secondary to disseminated invasive Aspergillus. This report describes the presentation of fungal thyroiditis secondary to disseminated invasive Aspergillus originating from the respiratory tract. The authors review the diagnostic challenges, pathophysiology, and treatment of this condition.http://dx.doi.org/10.1155/2013/741041 |
| spellingShingle | Madiha M. Alvi David S. Meyer Nicholas J. Hardin James G. deKay Annis M. Marney Matthew P. Gilbert Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient Case Reports in Endocrinology |
| title | Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient |
| title_full | Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient |
| title_fullStr | Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient |
| title_full_unstemmed | Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient |
| title_short | Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient |
| title_sort | aspergillus thyroiditis a complication of respiratory tract infection in an immunocompromised patient |
| url | http://dx.doi.org/10.1155/2013/741041 |
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