Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing
Regenerative medicine is a fast expanding scientific topic. One of the main areas of development directions in this field is the usage of additive manufacturing to fabricate functional components that would be later integrated directly into the human body. One such structure could be a microfluidic...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2022/9411024 |
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| author | Lucero Hernandez-Cedillo Deividas Andriukaitis Lukas Šerpytis Tomas Drevinskas Olga Kornyšova Vilma Kaškonienė Mantas Stankevičius Kristina Bimbiraitė-Survilienė Audrius Sigitas Maruška Linas Jonušauskas |
| author_facet | Lucero Hernandez-Cedillo Deividas Andriukaitis Lukas Šerpytis Tomas Drevinskas Olga Kornyšova Vilma Kaškonienė Mantas Stankevičius Kristina Bimbiraitė-Survilienė Audrius Sigitas Maruška Linas Jonušauskas |
| author_sort | Lucero Hernandez-Cedillo |
| collection | DOAJ |
| description | Regenerative medicine is a fast expanding scientific topic. One of the main areas of development directions in this field is the usage of additive manufacturing to fabricate functional components that would be later integrated directly into the human body. One such structure could be a microfluidic valve which could replace its biological counterpart in veins as it is worn out over the lifetime of a patient. In this work, we explore the possibility to produce such a structure by using multiphoton polymerization (MPP). This technology allows the creation of 3D structures on a micro- and nanometric scale. In this work, the fabrication of microfluidic systems by direct laser writing was carried out. These devices consist of a 100 μm diameter channel and within it a 200 μm long three-dimensional one-way mechanical valve. The idea of this device is to have a single flow direction for a fluid. For testing purposes, the valve was integrated into a femtosecond laser-made glass microfluidic system. Such a system acts as a platform for testing such small and delicate devices. Measurements of the dimensions of the device within such a testing platform were taken and the repeatability of this process was analyzed. The capability to use it for flow direction control is measured. Possible implications to the field of regenerative medicine are discussed. |
| format | Article |
| id | doaj-art-89c076a77e9540259ce25278d321edff |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-89c076a77e9540259ce25278d321edff2025-02-03T05:57:31ZengWileyApplied Bionics and Biomechanics1754-21032022-01-01202210.1155/2022/9411024Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser WritingLucero Hernandez-Cedillo0Deividas Andriukaitis1Lukas Šerpytis2Tomas Drevinskas3Olga Kornyšova4Vilma Kaškonienė5Mantas Stankevičius6Kristina Bimbiraitė-Survilienė7Audrius Sigitas Maruška8Linas Jonušauskas9Laser Research CenterLaser Research CenterInstitute of ChemistryInstrumental Analysis Open Access CentreInstrumental Analysis Open Access CentreInstrumental Analysis Open Access CentreInstrumental Analysis Open Access CentreInstrumental Analysis Open Access CentreInstrumental Analysis Open Access CentreLaser Research CenterRegenerative medicine is a fast expanding scientific topic. One of the main areas of development directions in this field is the usage of additive manufacturing to fabricate functional components that would be later integrated directly into the human body. One such structure could be a microfluidic valve which could replace its biological counterpart in veins as it is worn out over the lifetime of a patient. In this work, we explore the possibility to produce such a structure by using multiphoton polymerization (MPP). This technology allows the creation of 3D structures on a micro- and nanometric scale. In this work, the fabrication of microfluidic systems by direct laser writing was carried out. These devices consist of a 100 μm diameter channel and within it a 200 μm long three-dimensional one-way mechanical valve. The idea of this device is to have a single flow direction for a fluid. For testing purposes, the valve was integrated into a femtosecond laser-made glass microfluidic system. Such a system acts as a platform for testing such small and delicate devices. Measurements of the dimensions of the device within such a testing platform were taken and the repeatability of this process was analyzed. The capability to use it for flow direction control is measured. Possible implications to the field of regenerative medicine are discussed.http://dx.doi.org/10.1155/2022/9411024 |
| spellingShingle | Lucero Hernandez-Cedillo Deividas Andriukaitis Lukas Šerpytis Tomas Drevinskas Olga Kornyšova Vilma Kaškonienė Mantas Stankevičius Kristina Bimbiraitė-Survilienė Audrius Sigitas Maruška Linas Jonušauskas Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing Applied Bionics and Biomechanics |
| title | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
| title_full | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
| title_fullStr | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
| title_full_unstemmed | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
| title_short | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
| title_sort | peculiarities of integrating mechanical valves in microfluidic channels using direct laser writing |
| url | http://dx.doi.org/10.1155/2022/9411024 |
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