Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine
Musculoskeletal regenerative medicine is mainly based on the use of cell therapy to heal damaged tissues such as bone, cartilage, and tendons. Throughout the years, different cell types have been employed for the treatment of musculoskeletal diseases, in particular, mesenchymal stem cells (MSCs) der...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6632052 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561779925843968 |
|---|---|
| author | Francesca Veronesi Melania Maglio Deyanira Contartese Lucia Martini Aurelio Muttini Milena Fini |
| author_facet | Francesca Veronesi Melania Maglio Deyanira Contartese Lucia Martini Aurelio Muttini Milena Fini |
| author_sort | Francesca Veronesi |
| collection | DOAJ |
| description | Musculoskeletal regenerative medicine is mainly based on the use of cell therapy to heal damaged tissues such as bone, cartilage, and tendons. Throughout the years, different cell types have been employed for the treatment of musculoskeletal diseases, in particular, mesenchymal stem cells (MSCs) derived from bone marrow (BMSCs) and adipose tissue (ADSCs). Though the results of these literature studies have been encouraging, there are some limitations, especially on long-term results. Recently, some interest has shifted towards new cell types such as the stromal vascular fraction (SVF) and amniotic endothelial cells (AECs). The aim of the present literature review is to evaluate preclinical and clinical studies that used SVF and AECs for musculoskeletal tissue regeneration. Forty-eight preclinical and clinical studies, performed in the last 10 years, were identified. Both SVF and AECs, injected or implanted with or without scaffolds, were shown to be valid alternatives, and in some ways superior, to ADSCs and BMSCs, being able to differentiate towards osteogenic, chondrogenic, and tenogenic lineages, and to promote cell and tissue regenerative potential. The use of SVF and AECs could represent a new regenerative treatment in several musculoskeletal pathologies, solving the problem of cell expansion in vitro. |
| format | Article |
| id | doaj-art-89b628a5bd584d0383e887728feed35f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-89b628a5bd584d0383e887728feed35f2025-02-03T01:24:12ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66320526632052Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative MedicineFrancesca Veronesi0Melania Maglio1Deyanira Contartese2Lucia Martini3Aurelio Muttini4Milena Fini5IRCCS Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Via di Barbiano 1/10, 40136 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Via di Barbiano 1/10, 40136 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Via di Barbiano 1/10, 40136 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Via di Barbiano 1/10, 40136 Bologna, ItalyFaculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, ItalyIRCCS Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Via di Barbiano 1/10, 40136 Bologna, ItalyMusculoskeletal regenerative medicine is mainly based on the use of cell therapy to heal damaged tissues such as bone, cartilage, and tendons. Throughout the years, different cell types have been employed for the treatment of musculoskeletal diseases, in particular, mesenchymal stem cells (MSCs) derived from bone marrow (BMSCs) and adipose tissue (ADSCs). Though the results of these literature studies have been encouraging, there are some limitations, especially on long-term results. Recently, some interest has shifted towards new cell types such as the stromal vascular fraction (SVF) and amniotic endothelial cells (AECs). The aim of the present literature review is to evaluate preclinical and clinical studies that used SVF and AECs for musculoskeletal tissue regeneration. Forty-eight preclinical and clinical studies, performed in the last 10 years, were identified. Both SVF and AECs, injected or implanted with or without scaffolds, were shown to be valid alternatives, and in some ways superior, to ADSCs and BMSCs, being able to differentiate towards osteogenic, chondrogenic, and tenogenic lineages, and to promote cell and tissue regenerative potential. The use of SVF and AECs could represent a new regenerative treatment in several musculoskeletal pathologies, solving the problem of cell expansion in vitro.http://dx.doi.org/10.1155/2021/6632052 |
| spellingShingle | Francesca Veronesi Melania Maglio Deyanira Contartese Lucia Martini Aurelio Muttini Milena Fini Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine Stem Cells International |
| title | Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine |
| title_full | Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine |
| title_fullStr | Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine |
| title_full_unstemmed | Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine |
| title_short | Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine |
| title_sort | stromal vascular fraction and amniotic epithelial cells preclinical and clinical relevance in musculoskeletal regenerative medicine |
| url | http://dx.doi.org/10.1155/2021/6632052 |
| work_keys_str_mv | AT francescaveronesi stromalvascularfractionandamnioticepithelialcellspreclinicalandclinicalrelevanceinmusculoskeletalregenerativemedicine AT melaniamaglio stromalvascularfractionandamnioticepithelialcellspreclinicalandclinicalrelevanceinmusculoskeletalregenerativemedicine AT deyaniracontartese stromalvascularfractionandamnioticepithelialcellspreclinicalandclinicalrelevanceinmusculoskeletalregenerativemedicine AT luciamartini stromalvascularfractionandamnioticepithelialcellspreclinicalandclinicalrelevanceinmusculoskeletalregenerativemedicine AT aureliomuttini stromalvascularfractionandamnioticepithelialcellspreclinicalandclinicalrelevanceinmusculoskeletalregenerativemedicine AT milenafini stromalvascularfractionandamnioticepithelialcellspreclinicalandclinicalrelevanceinmusculoskeletalregenerativemedicine |