Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer s...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2020/7192896 |
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| author | Hang Su Chonghui Yang Chenrong Jin He Zhang Chengcheng Yin Yang Yang Haoyuan Chen Li Jing Bin Qi Daqing Zhao Xueyuan Bai Li Liu |
| author_facet | Hang Su Chonghui Yang Chenrong Jin He Zhang Chengcheng Yin Yang Yang Haoyuan Chen Li Jing Bin Qi Daqing Zhao Xueyuan Bai Li Liu |
| author_sort | Hang Su |
| collection | DOAJ |
| description | The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not. Our previous comparative study between sika deer and red deer suggests that the metabolic pathways between them are profoundly different based on protein level. Therefore, the metabolomic technology is used to identify and quantify the metabolites in antler samples, providing interesting insights into differential metabolite profile of antlers between sika deer and red deer. The distinct metabolic characteristics of sika deer compared to red deer provide an opportunity to explain why the red deer antler with a larger size. The enrichment analysis of differential metabolites showed that three pathways including glycine and serine metabolism, methionine metabolism, and pterine biosynthesis had a significant difference between two antler groups. |
| format | Article |
| id | doaj-art-89ac088e85244c308cce9918f390b88d |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-89ac088e85244c308cce9918f390b88d2025-02-03T05:49:53ZengWileyInternational Journal of Genomics2314-436X2314-43782020-01-01202010.1155/2020/71928967192896Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer AntlerHang Su0Chonghui Yang1Chenrong Jin2He Zhang3Chengcheng Yin4Yang Yang5Haoyuan Chen6Li Jing7Bin Qi8Daqing Zhao9Xueyuan Bai10Li Liu11Practice Innovations Center, Changchun University of Chinese Medicine, Changchun 130117, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaPractice Innovations Center, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaThe antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not. Our previous comparative study between sika deer and red deer suggests that the metabolic pathways between them are profoundly different based on protein level. Therefore, the metabolomic technology is used to identify and quantify the metabolites in antler samples, providing interesting insights into differential metabolite profile of antlers between sika deer and red deer. The distinct metabolic characteristics of sika deer compared to red deer provide an opportunity to explain why the red deer antler with a larger size. The enrichment analysis of differential metabolites showed that three pathways including glycine and serine metabolism, methionine metabolism, and pterine biosynthesis had a significant difference between two antler groups.http://dx.doi.org/10.1155/2020/7192896 |
| spellingShingle | Hang Su Chonghui Yang Chenrong Jin He Zhang Chengcheng Yin Yang Yang Haoyuan Chen Li Jing Bin Qi Daqing Zhao Xueyuan Bai Li Liu Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler International Journal of Genomics |
| title | Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler |
| title_full | Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler |
| title_fullStr | Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler |
| title_full_unstemmed | Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler |
| title_short | Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler |
| title_sort | comparative metabolomics study revealed difference in central carbon metabolism between sika deer and red deer antler |
| url | http://dx.doi.org/10.1155/2020/7192896 |
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