Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats
Isoniazid and rifampicin are reliable drugs against tuberculosis, but while effective, their use is associated with the risk of drug-induced liver damage. Embelin, a natural parabenzoquinone derived from the Embelia ribes plant, has gained attention for its potential therapeutic properties, anti...
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2024-06-01
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| Series: | The Ukrainian Biochemical Journal |
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| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2024/06/Mosa_96_3.pdf |
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| author | O. F. Mosa |
| author_facet | O. F. Mosa |
| author_sort | O. F. Mosa |
| collection | DOAJ |
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Isoniazid and rifampicin are reliable drugs against tuberculosis, but while effective, their use is associated with the risk of drug-induced liver damage. Embelin, a natural parabenzoquinone derived from the Embelia ribes plant, has gained attention for its potential therapeutic properties, antioxidant and organ-protective effects. The study aimed to assess the hepatoprotective properties of embelin against liver damage induced by isoniazid and rifampicin in rats. Wistar rats were used, and liver damage was induced by administration of isoniazid (100 mg/kg) and rifampicin (100 mg/kg). Embelin was given at doses of 50, 75, and 100 mg/kg for 21 days. All the drugs were given orally. Serum levels of the oxidative stress markers, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) activity measured by enzymatic assay kits (Elabscience, China), and the levels of tumour necrosis factor-α (TNF-α), interleukins IL-1β and IL-6 measured by ELISA kits (Randox, UK) were estimated. Embelin administration at varying doses effectively restored AST, ALT, ALP, SOD and catalase activity and notably decreased MDA and nitric oxide concentration as well as expression of inflammatory cytokines TNF-α, IL-1β and IL-6 in the serum of animals with drug-induced liver damage. These findings underscore embelin’s hepatoprotective effects, likely attributed to its radical scavenging properties and ability to suppress cytokine production. |
| format | Article |
| id | doaj-art-898b8f3dba744570a5a09eaa4a8db59e |
| institution | DOAJ |
| issn | 2409-4943 2413-5003 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj-art-898b8f3dba744570a5a09eaa4a8db59e2025-08-20T03:00:34ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032024-06-01963485610.15407/ubj96.03.048Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in ratsO. F. Mosa0https://orcid.org/0000-0001-5052-7116Public Health Department, College of Al-Lieth Health Science, Umm Al Qura University, Makkah, Saudi Arabia Isoniazid and rifampicin are reliable drugs against tuberculosis, but while effective, their use is associated with the risk of drug-induced liver damage. Embelin, a natural parabenzoquinone derived from the Embelia ribes plant, has gained attention for its potential therapeutic properties, antioxidant and organ-protective effects. The study aimed to assess the hepatoprotective properties of embelin against liver damage induced by isoniazid and rifampicin in rats. Wistar rats were used, and liver damage was induced by administration of isoniazid (100 mg/kg) and rifampicin (100 mg/kg). Embelin was given at doses of 50, 75, and 100 mg/kg for 21 days. All the drugs were given orally. Serum levels of the oxidative stress markers, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) activity measured by enzymatic assay kits (Elabscience, China), and the levels of tumour necrosis factor-α (TNF-α), interleukins IL-1β and IL-6 measured by ELISA kits (Randox, UK) were estimated. Embelin administration at varying doses effectively restored AST, ALT, ALP, SOD and catalase activity and notably decreased MDA and nitric oxide concentration as well as expression of inflammatory cytokines TNF-α, IL-1β and IL-6 in the serum of animals with drug-induced liver damage. These findings underscore embelin’s hepatoprotective effects, likely attributed to its radical scavenging properties and ability to suppress cytokine production.http://ukrbiochemjournal.org/wp-content/uploads/2024/06/Mosa_96_3.pdfantioxidant effectcytokine suppressionembelinhepatoprotectionisoniazidrifampicin |
| spellingShingle | O. F. Mosa Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats The Ukrainian Biochemical Journal antioxidant effect cytokine suppression embelin hepatoprotection isoniazid rifampicin |
| title | Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats |
| title_full | Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats |
| title_fullStr | Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats |
| title_full_unstemmed | Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats |
| title_short | Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats |
| title_sort | embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats |
| topic | antioxidant effect cytokine suppression embelin hepatoprotection isoniazid rifampicin |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2024/06/Mosa_96_3.pdf |
| work_keys_str_mv | AT ofmosa embelinmitigateshepatotoxicityinducedbyisoniazidandrifampicininrats |