Roles of Mesenchymal Stem Cells in Spinal Cord Injury
Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured sp...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/5251313 |
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| author | Jing Qu Huanxiang Zhang |
| author_facet | Jing Qu Huanxiang Zhang |
| author_sort | Jing Qu |
| collection | DOAJ |
| description | Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues in animal models, and therefore, there is much interest in the clinical use of these cells. However, many questions which are essential to improve the therapy effects remain unanswered. For instance, the functional roles and related molecular regulatory mechanisms of MSCs in vivo are not yet completely determined. It is important for transplanted cells to migrate into the injured tissue, to survive and undergo neural differentiation, or to play neural protection roles by various mechanisms after SCI. In this review, we will focus on some of the recent knowledge about the biological behavior and function of MSCs in SCI. Meanwhile, we highlight the function of biomaterials to direct the behavior of MSCs based on our series of work on silk fibroin biomaterials and attempt to emphasize combinational strategies such as tissue engineering for functional improvement of SCI. |
| format | Article |
| id | doaj-art-89899684ed6a43aaa6bca762366edd92 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-89899684ed6a43aaa6bca762366edd922025-02-03T01:09:00ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/52513135251313Roles of Mesenchymal Stem Cells in Spinal Cord InjuryJing Qu0Huanxiang Zhang1Department of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Medical College of Soochow University, Ren Ai Road 199, Suzhou Industrial Park, Suzhou 215123, ChinaDepartment of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Medical College of Soochow University, Ren Ai Road 199, Suzhou Industrial Park, Suzhou 215123, ChinaSpinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues in animal models, and therefore, there is much interest in the clinical use of these cells. However, many questions which are essential to improve the therapy effects remain unanswered. For instance, the functional roles and related molecular regulatory mechanisms of MSCs in vivo are not yet completely determined. It is important for transplanted cells to migrate into the injured tissue, to survive and undergo neural differentiation, or to play neural protection roles by various mechanisms after SCI. In this review, we will focus on some of the recent knowledge about the biological behavior and function of MSCs in SCI. Meanwhile, we highlight the function of biomaterials to direct the behavior of MSCs based on our series of work on silk fibroin biomaterials and attempt to emphasize combinational strategies such as tissue engineering for functional improvement of SCI.http://dx.doi.org/10.1155/2017/5251313 |
| spellingShingle | Jing Qu Huanxiang Zhang Roles of Mesenchymal Stem Cells in Spinal Cord Injury Stem Cells International |
| title | Roles of Mesenchymal Stem Cells in Spinal Cord Injury |
| title_full | Roles of Mesenchymal Stem Cells in Spinal Cord Injury |
| title_fullStr | Roles of Mesenchymal Stem Cells in Spinal Cord Injury |
| title_full_unstemmed | Roles of Mesenchymal Stem Cells in Spinal Cord Injury |
| title_short | Roles of Mesenchymal Stem Cells in Spinal Cord Injury |
| title_sort | roles of mesenchymal stem cells in spinal cord injury |
| url | http://dx.doi.org/10.1155/2017/5251313 |
| work_keys_str_mv | AT jingqu rolesofmesenchymalstemcellsinspinalcordinjury AT huanxiangzhang rolesofmesenchymalstemcellsinspinalcordinjury |