Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection
Differentiating BK virus nephropathy (BKVN) from acute rejection (AR) is crucial in clinical practice, as both of them have interstitial inflammation in the grafts. The purpose of the study is to describe the inflammatory cellular constituents of BKVN and to determine the clinical utility of immunop...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/412902 |
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| author | Xue Li Qiquan Sun Jinsong Chen Shuming Ji Jiqiu Wen Dongrei Cheng Zhihong Liu |
| author_facet | Xue Li Qiquan Sun Jinsong Chen Shuming Ji Jiqiu Wen Dongrei Cheng Zhihong Liu |
| author_sort | Xue Li |
| collection | DOAJ |
| description | Differentiating BK virus nephropathy (BKVN) from acute rejection (AR) is crucial in clinical practice, as both of them have interstitial inflammation in the grafts. The purpose of the study is to describe the inflammatory cellular constituents of BKVN and to determine the clinical utility of immunophenotyping findings in distinguishing BKVN from AR. In addition, the expression of the HLA-DR was investigated. Sixty-five renal allograft recipients were included in this study, including 22 cases of BKVN, 31 cases of AR, and 12 cases of stable allograft. Immunostaining for infiltrating lymphocytes showed that the number of CD20 cells (P<0.001) and the percentages of CD3 (P<0.001), CD4 (P=0.004), CD8 (P=0.005), and CD20 (P=0.002) cells were all significantly different between BKVN and AR. Moreover, there were no statistically significant differences in tubule cell HLA-DR expression (P=0.156). This observation suggests that the number of CD20 cells and the percentages of CD3, CD4, CD8, and CD20 cells in renal biopsies would aid the distinction between BKVN and AR. On the other hand, the presence of HLA-DR upregulation may not only be specific for acute rejection but also be a response to BKVN. |
| format | Article |
| id | doaj-art-8978456cc55e4f79a9b38e6f19e61166 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-8978456cc55e4f79a9b38e6f19e611662025-02-03T01:12:20ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/412902412902Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute RejectionXue Li0Qiquan Sun1Jinsong Chen2Shuming Ji3Jiqiu Wen4Dongrei Cheng5Zhihong Liu6Research Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaResearch Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaResearch Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaResearch Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaResearch Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaResearch Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaResearch Institute of Nephrology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhong Shan Road, Nanjing 210002, ChinaDifferentiating BK virus nephropathy (BKVN) from acute rejection (AR) is crucial in clinical practice, as both of them have interstitial inflammation in the grafts. The purpose of the study is to describe the inflammatory cellular constituents of BKVN and to determine the clinical utility of immunophenotyping findings in distinguishing BKVN from AR. In addition, the expression of the HLA-DR was investigated. Sixty-five renal allograft recipients were included in this study, including 22 cases of BKVN, 31 cases of AR, and 12 cases of stable allograft. Immunostaining for infiltrating lymphocytes showed that the number of CD20 cells (P<0.001) and the percentages of CD3 (P<0.001), CD4 (P=0.004), CD8 (P=0.005), and CD20 (P=0.002) cells were all significantly different between BKVN and AR. Moreover, there were no statistically significant differences in tubule cell HLA-DR expression (P=0.156). This observation suggests that the number of CD20 cells and the percentages of CD3, CD4, CD8, and CD20 cells in renal biopsies would aid the distinction between BKVN and AR. On the other hand, the presence of HLA-DR upregulation may not only be specific for acute rejection but also be a response to BKVN.http://dx.doi.org/10.1155/2013/412902 |
| spellingShingle | Xue Li Qiquan Sun Jinsong Chen Shuming Ji Jiqiu Wen Dongrei Cheng Zhihong Liu Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection Clinical and Developmental Immunology |
| title | Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection |
| title_full | Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection |
| title_fullStr | Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection |
| title_full_unstemmed | Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection |
| title_short | Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection |
| title_sort | immunophenotyping in bk virus allograft nephropathy distinct from acute rejection |
| url | http://dx.doi.org/10.1155/2013/412902 |
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