Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review
Leucine-rich repeat–containing G-protein-coupled receptors regulate stem cell activity and tissue homeostasis within female reproductive organs, primarily through their interaction with the Wnt/β-catenin signaling pathway. LGR4–6 are increasingly recognized for their roles in organ development, rege...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897241303441 |
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| author | Yu-Hsun Chang Kun-Chi Wu Kai-Hung Wang Dah-Ching Ding |
| author_facet | Yu-Hsun Chang Kun-Chi Wu Kai-Hung Wang Dah-Ching Ding |
| author_sort | Yu-Hsun Chang |
| collection | DOAJ |
| description | Leucine-rich repeat–containing G-protein-coupled receptors regulate stem cell activity and tissue homeostasis within female reproductive organs, primarily through their interaction with the Wnt/β-catenin signaling pathway. LGR4–6 are increasingly recognized for their roles in organ development, regeneration, and cancer. This review aims to provide a comprehensive overview of the roles of LGR4–6 in female reproductive organs, highlighting their significance in normal physiology and disease states, specifically in the context of ovarian cancer. LGR4 is essential for the proper development of the female reproductive system; its deficiency leads to significant reproductive abnormalities, including delayed menarche and follicle development issues. LGR5 is a well-established marker of stem cells in the ovary and fallopian tubes. It has been implicated in the pathogenesis of high-grade serous ovarian cancer. LGR6, while less studied, shares functional similarities with LGR5 and can maintain stemness. It contributes to chemoresistance in ovarian cancer. LGR6 is a marker for fallopian tube stem cells and is involved in stem cell maintenance and differentiation. LGR4–6 regulate the pathophysiology of female reproductive tissues. LGR4–6 are promising therapeutic targets for treating reproductive cancers and other related disorders. Molecular mechanisms underlying the functions of LGR4–6 should be studied. |
| format | Article |
| id | doaj-art-89714dea10da4134984b0a364d6b0dc6 |
| institution | Kabale University |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-89714dea10da4134984b0a364d6b0dc62025-01-28T22:03:57ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897241303441Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature ReviewYu-Hsun Chang0Kun-Chi Wu1Kai-Hung Wang2Dah-Ching Ding3Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, HualienDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, HualienDepartment of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, HualienInstitute of Medical Sciences, Tzu Chi University, HualienLeucine-rich repeat–containing G-protein-coupled receptors regulate stem cell activity and tissue homeostasis within female reproductive organs, primarily through their interaction with the Wnt/β-catenin signaling pathway. LGR4–6 are increasingly recognized for their roles in organ development, regeneration, and cancer. This review aims to provide a comprehensive overview of the roles of LGR4–6 in female reproductive organs, highlighting their significance in normal physiology and disease states, specifically in the context of ovarian cancer. LGR4 is essential for the proper development of the female reproductive system; its deficiency leads to significant reproductive abnormalities, including delayed menarche and follicle development issues. LGR5 is a well-established marker of stem cells in the ovary and fallopian tubes. It has been implicated in the pathogenesis of high-grade serous ovarian cancer. LGR6, while less studied, shares functional similarities with LGR5 and can maintain stemness. It contributes to chemoresistance in ovarian cancer. LGR6 is a marker for fallopian tube stem cells and is involved in stem cell maintenance and differentiation. LGR4–6 regulate the pathophysiology of female reproductive tissues. LGR4–6 are promising therapeutic targets for treating reproductive cancers and other related disorders. Molecular mechanisms underlying the functions of LGR4–6 should be studied.https://doi.org/10.1177/09636897241303441 |
| spellingShingle | Yu-Hsun Chang Kun-Chi Wu Kai-Hung Wang Dah-Ching Ding Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review Cell Transplantation |
| title | Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review |
| title_full | Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review |
| title_fullStr | Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review |
| title_full_unstemmed | Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review |
| title_short | Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review |
| title_sort | role of leucine rich repeat containing g protein coupled receptors 4 6 lgr4 6 in the ovary and other female reproductive organs a literature review |
| url | https://doi.org/10.1177/09636897241303441 |
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