Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity
Immunoglobulin A tissue transglutaminase is the single most efficient serological test for the diagnosis of celiac disease. It is well known that immunoglobulin A tissue transglutaminase levels correlate with the degree of intestinal damage, and that values can fluctuate in patients over time. Serol...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2011/642452 |
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| _version_ | 1832546000403693568 |
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| author | David Armstrong Andrew C Don-Wauchope Elena F Verdu |
| author_facet | David Armstrong Andrew C Don-Wauchope Elena F Verdu |
| author_sort | David Armstrong |
| collection | DOAJ |
| description | Immunoglobulin A tissue transglutaminase is the single most efficient serological test for the diagnosis of celiac disease. It is well known that immunoglobulin A tissue transglutaminase levels correlate with the degree of intestinal damage, and that values can fluctuate in patients over time. Serological testing can be used to identify symptomatic individuals that need a confirmatory biopsy, to screen at-risk populations or to monitor diet compliance in patients previously diagnosed with celiac disease. Thus, interpretation of serological testing requires consideration of the full clinical scenario. Antigliadin tests are no longer recommended for the diagnosis of classical celiac disease. However, our understanding of the pathogenesis and spectrum of gluten sensitivity has improved, and gluten-sensitive irritable bowel syndrome patients are increasingly being recognized. Studies are needed to determine the clinical utility of antigliadin serology in the diagnosis of gluten sensitivity. |
| format | Article |
| id | doaj-art-8970d8e62b244089bfef8fee0a774d5a |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-8970d8e62b244089bfef8fee0a774d5a2025-02-03T07:24:05ZengWileyCanadian Journal of Gastroenterology0835-79002011-01-0125419319710.1155/2011/642452Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten SensitivityDavid Armstrong0Andrew C Don-Wauchope1Elena F Verdu2Farncombe Family Digestive Health Research Institute and Division of Gastroenterology, CanadaDepartment of Pathology and Molecular Medicine and Department of Medicine, McMaster University, Hamilton, Ontario, CanadaFarncombe Family Digestive Health Research Institute and Division of Gastroenterology, CanadaImmunoglobulin A tissue transglutaminase is the single most efficient serological test for the diagnosis of celiac disease. It is well known that immunoglobulin A tissue transglutaminase levels correlate with the degree of intestinal damage, and that values can fluctuate in patients over time. Serological testing can be used to identify symptomatic individuals that need a confirmatory biopsy, to screen at-risk populations or to monitor diet compliance in patients previously diagnosed with celiac disease. Thus, interpretation of serological testing requires consideration of the full clinical scenario. Antigliadin tests are no longer recommended for the diagnosis of classical celiac disease. However, our understanding of the pathogenesis and spectrum of gluten sensitivity has improved, and gluten-sensitive irritable bowel syndrome patients are increasingly being recognized. Studies are needed to determine the clinical utility of antigliadin serology in the diagnosis of gluten sensitivity.http://dx.doi.org/10.1155/2011/642452 |
| spellingShingle | David Armstrong Andrew C Don-Wauchope Elena F Verdu Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity Canadian Journal of Gastroenterology |
| title | Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity |
| title_full | Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity |
| title_fullStr | Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity |
| title_full_unstemmed | Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity |
| title_short | Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity |
| title_sort | testing for gluten related disorders in clinical practice the role of serology in managing the spectrum of gluten sensitivity |
| url | http://dx.doi.org/10.1155/2011/642452 |
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