Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy

A 64-year-old man was diagnosed with invasive bladder and right lower ureteral urothelial cancer with right pelvic lymph node and lung metastases. He received four courses of gemcitabine and cisplatin therapy. He underwent lung metastasectomy and radical cystoprostatectomy, with not only primary les...

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Main Authors: Kyohei Ishida, Go Hasegawa, Takehisa Hashimoto, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Case Reports in Urology
Online Access:http://dx.doi.org/10.1155/2024/5586448
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author Kyohei Ishida
Go Hasegawa
Takehisa Hashimoto
Yohei Ikeda
Noboru Hara
Tsutomu Nishiyama
author_facet Kyohei Ishida
Go Hasegawa
Takehisa Hashimoto
Yohei Ikeda
Noboru Hara
Tsutomu Nishiyama
author_sort Kyohei Ishida
collection DOAJ
description A 64-year-old man was diagnosed with invasive bladder and right lower ureteral urothelial cancer with right pelvic lymph node and lung metastases. He received four courses of gemcitabine and cisplatin therapy. He underwent lung metastasectomy and radical cystoprostatectomy, with not only primary lesions but also metastatic lesions showing a complete response. New multiple lung metastases were revealed five months after adjuvant chemotherapy. On starting pembrolizumab therapy, the metastatic lesions are notably reduced in size. He is currently receiving pembrolizumab therapy, and no recurrence has been observed for over one year.
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institution Kabale University
issn 2090-6978
language English
publishDate 2024-01-01
publisher Wiley
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series Case Reports in Urology
spelling doaj-art-89518e93423642f799b969f2e31b4f072025-02-03T05:57:04ZengWileyCase Reports in Urology2090-69782024-01-01202410.1155/2024/5586448Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin TherapyKyohei Ishida0Go Hasegawa1Takehisa Hashimoto2Yohei Ikeda3Noboru Hara4Tsutomu Nishiyama5Department of UrologyDepartment of PathologyDepartment of Respiratory SurgeryDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of UrologyA 64-year-old man was diagnosed with invasive bladder and right lower ureteral urothelial cancer with right pelvic lymph node and lung metastases. He received four courses of gemcitabine and cisplatin therapy. He underwent lung metastasectomy and radical cystoprostatectomy, with not only primary lesions but also metastatic lesions showing a complete response. New multiple lung metastases were revealed five months after adjuvant chemotherapy. On starting pembrolizumab therapy, the metastatic lesions are notably reduced in size. He is currently receiving pembrolizumab therapy, and no recurrence has been observed for over one year.http://dx.doi.org/10.1155/2024/5586448
spellingShingle Kyohei Ishida
Go Hasegawa
Takehisa Hashimoto
Yohei Ikeda
Noboru Hara
Tsutomu Nishiyama
Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy
Case Reports in Urology
title Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy
title_full Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy
title_fullStr Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy
title_full_unstemmed Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy
title_short Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy
title_sort pembrolizumab therapy leading to complete remission for recurrence of pulmonary metastases after their resection and radical cystectomy following gemcitabine and cisplatin therapy
url http://dx.doi.org/10.1155/2024/5586448
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