Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction
We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B—probably reflecting brain and adipose tissue inflammation—in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, giv...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/790605 |
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| author | Theodora Boutsikou George Mastorakos Marialena Kyriakakou Alexandra Margeli Demetrios Hassiakos Ioannis Papassotiriou Christina Kanaka-Gantenbein Ariadne Malamitsi-Puchner |
| author_facet | Theodora Boutsikou George Mastorakos Marialena Kyriakakou Alexandra Margeli Demetrios Hassiakos Ioannis Papassotiriou Christina Kanaka-Gantenbein Ariadne Malamitsi-Puchner |
| author_sort | Theodora Boutsikou |
| collection | DOAJ |
| description | We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B—probably reflecting brain and adipose tissue inflammation—in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation. Serum hs-CRP, PAI-1, and S100B levels were measured in 40 mothers, and their 20 AGA and 20 IUGR full-term fetuses and neonates on postnatal days 1 and 4. hs-CRP, PAI-1, and S100B levels did not differ at all time points between AGA and IUGR groups. We conclude that the lack of difference in hs-CRP, PAI-1 and S100B levels, between IUGR and AGA fetuses/neonates—despite the lower birth weight, reflecting reduced fat mass in the former—might indicate more intense adipose tissue and nervous system inflammation in IUGRs. However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g. preeclampsia), cannot be excluded. |
| format | Article |
| id | doaj-art-893e5566780844a795d30d3bffb85bfb |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-893e5566780844a795d30d3bffb85bfb2025-02-03T06:07:56ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/790605790605Circulating Levels of Inflammatory Markers in Intrauterine Growth RestrictionTheodora Boutsikou0George Mastorakos1Marialena Kyriakakou2Alexandra Margeli3Demetrios Hassiakos4Ioannis Papassotiriou5Christina Kanaka-Gantenbein6Ariadne Malamitsi-Puchner7Neonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, GreeceDepartment of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, 11527 Athens, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, GreeceDepartment of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, 11527 Athens, GreeceFirst Department of Pediatrics, University of Athens, 11527 Athens, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, GreeceWe aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B—probably reflecting brain and adipose tissue inflammation—in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation. Serum hs-CRP, PAI-1, and S100B levels were measured in 40 mothers, and their 20 AGA and 20 IUGR full-term fetuses and neonates on postnatal days 1 and 4. hs-CRP, PAI-1, and S100B levels did not differ at all time points between AGA and IUGR groups. We conclude that the lack of difference in hs-CRP, PAI-1 and S100B levels, between IUGR and AGA fetuses/neonates—despite the lower birth weight, reflecting reduced fat mass in the former—might indicate more intense adipose tissue and nervous system inflammation in IUGRs. However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g. preeclampsia), cannot be excluded.http://dx.doi.org/10.1155/2010/790605 |
| spellingShingle | Theodora Boutsikou George Mastorakos Marialena Kyriakakou Alexandra Margeli Demetrios Hassiakos Ioannis Papassotiriou Christina Kanaka-Gantenbein Ariadne Malamitsi-Puchner Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction Mediators of Inflammation |
| title | Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction |
| title_full | Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction |
| title_fullStr | Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction |
| title_full_unstemmed | Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction |
| title_short | Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction |
| title_sort | circulating levels of inflammatory markers in intrauterine growth restriction |
| url | http://dx.doi.org/10.1155/2010/790605 |
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