Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor
Abstract We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-024-01621-6 |
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| _version_ | 1832571941511233536 |
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| author | Joshua D. Grill Daniel Gillen |
| author_facet | Joshua D. Grill Daniel Gillen |
| author_sort | Joshua D. Grill |
| collection | DOAJ |
| description | Abstract We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies. |
| format | Article |
| id | doaj-art-893a8877eb9b4f6e9cba7ac796896774 |
| institution | Kabale University |
| issn | 1758-9193 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj-art-893a8877eb9b4f6e9cba7ac7968967742025-02-02T12:11:58ZengBMCAlzheimer’s Research & Therapy1758-91932025-02-011711310.1186/s13195-024-01621-6Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigorJoshua D. Grill0Daniel Gillen1Institute for Memory Impairments and Neurological Disorders, University of California IrvineInstitute for Memory Impairments and Neurological Disorders, University of California IrvineAbstract We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies.https://doi.org/10.1186/s13195-024-01621-6DementiaMCIInterventionTrialRigorReproducibility |
| spellingShingle | Joshua D. Grill Daniel Gillen Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor Alzheimer’s Research & Therapy Dementia MCI Intervention Trial Rigor Reproducibility |
| title | Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor |
| title_full | Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor |
| title_fullStr | Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor |
| title_full_unstemmed | Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor |
| title_short | Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor |
| title_sort | effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to alzheimer s disease the need for rigor |
| topic | Dementia MCI Intervention Trial Rigor Reproducibility |
| url | https://doi.org/10.1186/s13195-024-01621-6 |
| work_keys_str_mv | AT joshuadgrill effectsofintensivelifestylechangesontheprogressionofmildcognitiveimpairmentorearlydementiaduetoalzheimersdiseasetheneedforrigor AT danielgillen effectsofintensivelifestylechangesontheprogressionofmildcognitiveimpairmentorearlydementiaduetoalzheimersdiseasetheneedforrigor |