Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review
Purpose. A case series of icatibant use in intubated patients with angiotensin-converting enzyme inhibitor- (ACEI-) induced angioedema is presented along with a relevant literature review and recommendations for utilization. Summary. Three intubated patients admitted to the intensive care unit for A...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2018/8081607 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560401264410624 |
|---|---|
| author | Erin K. Yeung Haritha Saikumar Jose Castaneda-Nerio Sandra G. Adams Mark Wong |
| author_facet | Erin K. Yeung Haritha Saikumar Jose Castaneda-Nerio Sandra G. Adams Mark Wong |
| author_sort | Erin K. Yeung |
| collection | DOAJ |
| description | Purpose. A case series of icatibant use in intubated patients with angiotensin-converting enzyme inhibitor- (ACEI-) induced angioedema is presented along with a relevant literature review and recommendations for utilization. Summary. Three intubated patients admitted to the intensive care unit for ACEI-induced angioedema were treated with icatibant. A literature search identified one controlled study and four case reports describing the use of icatibant in intubated ACEI-induced angioedema patients. Conclusion. Icatibant administration in intubated patients may be beneficial in decreasing time to extubation and length of intensive care unit stay. In the three cases described, icatibant administration did not appear to elicit a response in intubated patients, which has been described in previous case reports. For clinicians considering icatibant in the treatment of ACEI-induced angioedema, earlier administration upon arrival to the ED or immediately upon arriving to the intensive care unit is strongly advised. The suggested benefit of icatibant in intubated ACEI-induced angioedema patients should be verified by randomized clinical trials and cost-benefit analyses should be performed at individual institutions. |
| format | Article |
| id | doaj-art-8938363dcb8d4d54b630bd2d1bb0e664 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-8938363dcb8d4d54b630bd2d1bb0e6642025-02-03T01:27:40ZengWileyCase Reports in Critical Care2090-64202090-64392018-01-01201810.1155/2018/80816078081607Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature ReviewErin K. Yeung0Haritha Saikumar1Jose Castaneda-Nerio2Sandra G. Adams3Mark Wong4Department of Pharmacy Services, South Texas Veterans Health Care System, 7400 Merton Minter, San Antonio, TX 78229, USAMedicine Service, Pulmonary/Critical Care Division, South Texas Veterans Health Care System, 7400 Merton Minter (111E), San Antonio, TX 78229, USAMedicine Service, Pulmonary/Critical Care Division, South Texas Veterans Health Care System, 7400 Merton Minter (111E), San Antonio, TX 78229, USAMedicine Service, Pulmonary/Critical Care Division, South Texas Veterans Health Care System, 7400 Merton Minter (111E), San Antonio, TX 78229, USADepartment of Pharmacy Services, South Texas Veterans Health Care System, 7400 Merton Minter, San Antonio, TX 78229, USAPurpose. A case series of icatibant use in intubated patients with angiotensin-converting enzyme inhibitor- (ACEI-) induced angioedema is presented along with a relevant literature review and recommendations for utilization. Summary. Three intubated patients admitted to the intensive care unit for ACEI-induced angioedema were treated with icatibant. A literature search identified one controlled study and four case reports describing the use of icatibant in intubated ACEI-induced angioedema patients. Conclusion. Icatibant administration in intubated patients may be beneficial in decreasing time to extubation and length of intensive care unit stay. In the three cases described, icatibant administration did not appear to elicit a response in intubated patients, which has been described in previous case reports. For clinicians considering icatibant in the treatment of ACEI-induced angioedema, earlier administration upon arrival to the ED or immediately upon arriving to the intensive care unit is strongly advised. The suggested benefit of icatibant in intubated ACEI-induced angioedema patients should be verified by randomized clinical trials and cost-benefit analyses should be performed at individual institutions.http://dx.doi.org/10.1155/2018/8081607 |
| spellingShingle | Erin K. Yeung Haritha Saikumar Jose Castaneda-Nerio Sandra G. Adams Mark Wong Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review Case Reports in Critical Care |
| title | Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review |
| title_full | Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review |
| title_fullStr | Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review |
| title_full_unstemmed | Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review |
| title_short | Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review |
| title_sort | icatibant for angiotensin converting enzyme inhibitor induced angioedema in intubated patients case series and literature review |
| url | http://dx.doi.org/10.1155/2018/8081607 |
| work_keys_str_mv | AT erinkyeung icatibantforangiotensinconvertingenzymeinhibitorinducedangioedemainintubatedpatientscaseseriesandliteraturereview AT harithasaikumar icatibantforangiotensinconvertingenzymeinhibitorinducedangioedemainintubatedpatientscaseseriesandliteraturereview AT josecastanedanerio icatibantforangiotensinconvertingenzymeinhibitorinducedangioedemainintubatedpatientscaseseriesandliteraturereview AT sandragadams icatibantforangiotensinconvertingenzymeinhibitorinducedangioedemainintubatedpatientscaseseriesandliteraturereview AT markwong icatibantforangiotensinconvertingenzymeinhibitorinducedangioedemainintubatedpatientscaseseriesandliteraturereview |