Targeting Adult Neurogenesis for Poststroke Therapy
Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integratio...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/5868632 |
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| _version_ | 1832565457314381824 |
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| author | Jianfei Lu Anatol Manaenko Qin Hu |
| author_facet | Jianfei Lu Anatol Manaenko Qin Hu |
| author_sort | Jianfei Lu |
| collection | DOAJ |
| description | Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ and SGZ. This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery. Thus, enhancing the endogenous neurogenesis driven by ischemia and promoting the survival of newborn neurons can be promising therapeutic interventions for stroke. Here, we present an overview of the process of adult neurogenesis and the potential of stroke-induced neurogenesis on brain repair. |
| format | Article |
| id | doaj-art-893445dcccdd48e4aeb314f99f481f44 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-893445dcccdd48e4aeb314f99f481f442025-02-03T01:07:32ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/58686325868632Targeting Adult Neurogenesis for Poststroke TherapyJianfei Lu0Anatol Manaenko1Qin Hu2Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartments of Neurology, University of Erlangen-Nuremberg, Erlangen, GermanyDiscipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaAdult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ and SGZ. This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery. Thus, enhancing the endogenous neurogenesis driven by ischemia and promoting the survival of newborn neurons can be promising therapeutic interventions for stroke. Here, we present an overview of the process of adult neurogenesis and the potential of stroke-induced neurogenesis on brain repair.http://dx.doi.org/10.1155/2017/5868632 |
| spellingShingle | Jianfei Lu Anatol Manaenko Qin Hu Targeting Adult Neurogenesis for Poststroke Therapy Stem Cells International |
| title | Targeting Adult Neurogenesis for Poststroke Therapy |
| title_full | Targeting Adult Neurogenesis for Poststroke Therapy |
| title_fullStr | Targeting Adult Neurogenesis for Poststroke Therapy |
| title_full_unstemmed | Targeting Adult Neurogenesis for Poststroke Therapy |
| title_short | Targeting Adult Neurogenesis for Poststroke Therapy |
| title_sort | targeting adult neurogenesis for poststroke therapy |
| url | http://dx.doi.org/10.1155/2017/5868632 |
| work_keys_str_mv | AT jianfeilu targetingadultneurogenesisforpoststroketherapy AT anatolmanaenko targetingadultneurogenesisforpoststroketherapy AT qinhu targetingadultneurogenesisforpoststroketherapy |