Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian
Due to the proved clinical efficacy, Shuang-Huang-Lian (SHL) has developed a variety of dosage forms. However, the in-depth research on targets and pharmacological mechanisms of SHL preparations was scarce. In the presented study, the bioinformatics approaches were adopted to integrate relevant data...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/291680 |
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| _version_ | 1832562618536034304 |
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| author | Bai-xia Zhang Jian Li Hao Gu Qiang Li Qi Zhang Tian-jiao Zhang Yun Wang Cheng-ke Cai |
| author_facet | Bai-xia Zhang Jian Li Hao Gu Qiang Li Qi Zhang Tian-jiao Zhang Yun Wang Cheng-ke Cai |
| author_sort | Bai-xia Zhang |
| collection | DOAJ |
| description | Due to the proved clinical efficacy, Shuang-Huang-Lian (SHL) has
developed a variety of dosage forms. However, the in-depth
research on targets and pharmacological mechanisms of SHL
preparations was scarce. In the presented study, the
bioinformatics approaches were adopted to integrate relevant data
and biological information. As a result, a PPI network was built
and the common topological parameters were characterized. The
results suggested that the PPI network of SHL exhibited a
scale-free property and modular architecture. The drug target
network of SHL was structured with 21 functional modules.
According to certain modules and pharmacological effects
distribution, an antitumor effect and potential drug targets were
predicted. A biological network which contained 26 subnetworks was
constructed to elucidate the antipneumonia mechanism of SHL. We
also extracted the subnetwork to explicitly display the pathway
where one effective component acts on the pneumonia related
targets. In conclusions, a bioinformatics approach was established
for exploring the drug targets, pharmacological activity
distribution, effective components of SHL, and its mechanism of
antipneumonia. Above all, we identified the effective components
and disclosed the mechanism of SHL from the view of system. |
| format | Article |
| id | doaj-art-8930a007f4dc4d77a6c4ab545ce672e9 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8930a007f4dc4d77a6c4ab545ce672e92025-02-03T01:22:15ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/291680291680Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-LianBai-xia Zhang0Jian Li1Hao Gu2Qiang Li3Qi Zhang4Tian-jiao Zhang5Yun Wang6Cheng-ke Cai7School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, ChinaInstitute of Basic Research of Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, ChinaDue to the proved clinical efficacy, Shuang-Huang-Lian (SHL) has developed a variety of dosage forms. However, the in-depth research on targets and pharmacological mechanisms of SHL preparations was scarce. In the presented study, the bioinformatics approaches were adopted to integrate relevant data and biological information. As a result, a PPI network was built and the common topological parameters were characterized. The results suggested that the PPI network of SHL exhibited a scale-free property and modular architecture. The drug target network of SHL was structured with 21 functional modules. According to certain modules and pharmacological effects distribution, an antitumor effect and potential drug targets were predicted. A biological network which contained 26 subnetworks was constructed to elucidate the antipneumonia mechanism of SHL. We also extracted the subnetwork to explicitly display the pathway where one effective component acts on the pneumonia related targets. In conclusions, a bioinformatics approach was established for exploring the drug targets, pharmacological activity distribution, effective components of SHL, and its mechanism of antipneumonia. Above all, we identified the effective components and disclosed the mechanism of SHL from the view of system.http://dx.doi.org/10.1155/2015/291680 |
| spellingShingle | Bai-xia Zhang Jian Li Hao Gu Qiang Li Qi Zhang Tian-jiao Zhang Yun Wang Cheng-ke Cai Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian The Scientific World Journal |
| title | Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian |
| title_full | Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian |
| title_fullStr | Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian |
| title_full_unstemmed | Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian |
| title_short | Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian |
| title_sort | using bioinformatics approach to explore the pharmacological mechanisms of multiple ingredients in shuang huang lian |
| url | http://dx.doi.org/10.1155/2015/291680 |
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