Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study
Aim. The aim of present study was to determine the safety and efficacy of a new renal artery denervation system for treatment of hypertensive patients. Methods. Hypertensive patients with mean office systolic blood pressure ≥150mmHg and ≤180mmHg or an average of 24-hour ambulatory systolic blood pre...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2019/7929706 |
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| author | Yang Li Abdul Qadir Nawabi Yi Feng Qiming Dai Genshan Ma Naifeng Liu |
| author_facet | Yang Li Abdul Qadir Nawabi Yi Feng Qiming Dai Genshan Ma Naifeng Liu |
| author_sort | Yang Li |
| collection | DOAJ |
| description | Aim. The aim of present study was to determine the safety and efficacy of a new renal artery denervation system for treatment of hypertensive patients. Methods. Hypertensive patients with mean office systolic blood pressure ≥150mmHg and ≤180mmHg or an average of 24-hour ambulatory systolic blood pressure ≥145mmHg and ≤170mmHg after stopping hypertensive medications for 2 weeks or more were enrolled to undergo renal denervation (RDN) using a new RDN system. Changes in office blood pressure and mean 24-hour ambulatory blood pressure and safety were assessed after 6 months. Results. Fifteen patients underwent RDN and followed up for 6 months. At the 6-month follow-up, office systolic blood pressure decreased 11.5±9.9mmHg (P<0.01) and office diastolic blood pressure decreased 6.9±4.8mmHg (P<0.01); mean 24-hour ambulatory systolic blood pressure decreased 7.5±7.7mmHg (P<0.05) and mean 24-hour diastolic blood pressure decreased 3.3±4.7mmHg (P>0.05) compared to baseline values. There were no serious RDN-related adverse events during follow-up. Conclusion. Our results demonstrate that the new RDN system is safe and could significantly reduce blood pressure in hypertensive patients in the absence of antihypertensive medications. This trial is registered with ChiCTR1800017815. |
| format | Article |
| id | doaj-art-8928c784377b4181b0c69358b86d38fc |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-8928c784377b4181b0c69358b86d38fc2025-02-03T06:07:54ZengWileyInternational Journal of Hypertension2090-03842090-03922019-01-01201910.1155/2019/79297067929706Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot StudyYang Li0Abdul Qadir Nawabi1Yi Feng2Qiming Dai3Genshan Ma4Naifeng Liu5Department of Cardiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjia Bridge Road, Nanjing 210009, ChinaDepartment of Cardiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjia Bridge Road, Nanjing 210009, ChinaDepartment of Cardiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjia Bridge Road, Nanjing 210009, ChinaDepartment of Cardiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjia Bridge Road, Nanjing 210009, ChinaDepartment of Cardiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjia Bridge Road, Nanjing 210009, ChinaDepartment of Cardiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjia Bridge Road, Nanjing 210009, ChinaAim. The aim of present study was to determine the safety and efficacy of a new renal artery denervation system for treatment of hypertensive patients. Methods. Hypertensive patients with mean office systolic blood pressure ≥150mmHg and ≤180mmHg or an average of 24-hour ambulatory systolic blood pressure ≥145mmHg and ≤170mmHg after stopping hypertensive medications for 2 weeks or more were enrolled to undergo renal denervation (RDN) using a new RDN system. Changes in office blood pressure and mean 24-hour ambulatory blood pressure and safety were assessed after 6 months. Results. Fifteen patients underwent RDN and followed up for 6 months. At the 6-month follow-up, office systolic blood pressure decreased 11.5±9.9mmHg (P<0.01) and office diastolic blood pressure decreased 6.9±4.8mmHg (P<0.01); mean 24-hour ambulatory systolic blood pressure decreased 7.5±7.7mmHg (P<0.05) and mean 24-hour diastolic blood pressure decreased 3.3±4.7mmHg (P>0.05) compared to baseline values. There were no serious RDN-related adverse events during follow-up. Conclusion. Our results demonstrate that the new RDN system is safe and could significantly reduce blood pressure in hypertensive patients in the absence of antihypertensive medications. This trial is registered with ChiCTR1800017815.http://dx.doi.org/10.1155/2019/7929706 |
| spellingShingle | Yang Li Abdul Qadir Nawabi Yi Feng Qiming Dai Genshan Ma Naifeng Liu Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study International Journal of Hypertension |
| title | Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study |
| title_full | Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study |
| title_fullStr | Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study |
| title_full_unstemmed | Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study |
| title_short | Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study |
| title_sort | safety and efficacy of a new renal denervation catheter in hypertensive patients in the absent of antihypertensive medications a pilot study |
| url | http://dx.doi.org/10.1155/2019/7929706 |
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