Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies
Aims. Although several epidemiological studies have investigated the relationship between diabetes mellitus (DM) and the risk of gout, the results are inconsistent. Therefore, we systematically retrospected available observational studies to clarify the impact of DM on the risk of gout. Methods. Emb...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5470739 |
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| author | Xiaoli Li Lianju Li Yuling Xing Tiantian Cheng Shaohui Ren Huijuan Ma |
| author_facet | Xiaoli Li Lianju Li Yuling Xing Tiantian Cheng Shaohui Ren Huijuan Ma |
| author_sort | Xiaoli Li |
| collection | DOAJ |
| description | Aims. Although several epidemiological studies have investigated the relationship between diabetes mellitus (DM) and the risk of gout, the results are inconsistent. Therefore, we systematically retrospected available observational studies to clarify the impact of DM on the risk of gout. Methods. Embase, PubMed, Cochrane Library, Scopus, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles from inception to 2 March 2020. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. The multivariate adjusted relative risks (aRR) and corresponding 95% confidence intervals (CI) were pooled based on a random-effect model. Cochran’s Q test and I2 were used to evaluate heterogeneity. Results. Five studies involving 863,755 participants were included in our meta-analysis. DM was associated with a lower risk of gout (aRR: 0.66; 95% CI: 0.59 to 0.73) but had a high heterogeneity (I2=89.2%). Metaregression analysis revealed that the types of DM were the source of heterogeneity. Subgroup analysis by types of DM showed that the risk of gout was significantly lower in type 1 DM (T1DM) (aRR: 0.42; 95% CI: 0.28 to 0.63) than in type 2 DM (T2DM) (aRR: 0.72; 95% CI: 0.70 to 0.74). Furthermore, when stratified according to gender in DM, sex-specific association was found. The inverse association was observed in males only (aRR: 0.57; 95% CI: 0.43 to 0.77) and not in females (aRR: 0.96; 95% CI: 0.87 to 1.05). Further stratified based on glycated hemoglobin (HbA1c) levels in DM, raised A1C levels were associated with a reduced risk of gout in patients with DM. Conclusions. This meta-analysis indicated that DM was related to a lower risk of gout, and the protective effect of DM on the risk of gout was stronger in males, T1DM, or DM with high HbA1c levels. However, more prospective cohort studies are required to confirm these results. |
| format | Article |
| id | doaj-art-891fb2e6d9524be88ec3c817edcc7e99 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-891fb2e6d9524be88ec3c817edcc7e992025-02-03T00:58:42ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/54707395470739Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational StudiesXiaoli Li0Lianju Li1Yuling Xing2Tiantian Cheng3Shaohui Ren4Huijuan Ma5Department of Rheumatology, Xingtai People’s Hospital Affiliated to Hebei Medical University, Xingtai 054001, ChinaDepartment of Rheumatology, Xingtai People’s Hospital Affiliated to Hebei Medical University, Xingtai 054001, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, ChinaDepartment of Medicine, Xingtai People’s Hospital Affiliated to Hebei Medical University, Xingtai 054001, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaAims. Although several epidemiological studies have investigated the relationship between diabetes mellitus (DM) and the risk of gout, the results are inconsistent. Therefore, we systematically retrospected available observational studies to clarify the impact of DM on the risk of gout. Methods. Embase, PubMed, Cochrane Library, Scopus, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles from inception to 2 March 2020. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. The multivariate adjusted relative risks (aRR) and corresponding 95% confidence intervals (CI) were pooled based on a random-effect model. Cochran’s Q test and I2 were used to evaluate heterogeneity. Results. Five studies involving 863,755 participants were included in our meta-analysis. DM was associated with a lower risk of gout (aRR: 0.66; 95% CI: 0.59 to 0.73) but had a high heterogeneity (I2=89.2%). Metaregression analysis revealed that the types of DM were the source of heterogeneity. Subgroup analysis by types of DM showed that the risk of gout was significantly lower in type 1 DM (T1DM) (aRR: 0.42; 95% CI: 0.28 to 0.63) than in type 2 DM (T2DM) (aRR: 0.72; 95% CI: 0.70 to 0.74). Furthermore, when stratified according to gender in DM, sex-specific association was found. The inverse association was observed in males only (aRR: 0.57; 95% CI: 0.43 to 0.77) and not in females (aRR: 0.96; 95% CI: 0.87 to 1.05). Further stratified based on glycated hemoglobin (HbA1c) levels in DM, raised A1C levels were associated with a reduced risk of gout in patients with DM. Conclusions. This meta-analysis indicated that DM was related to a lower risk of gout, and the protective effect of DM on the risk of gout was stronger in males, T1DM, or DM with high HbA1c levels. However, more prospective cohort studies are required to confirm these results.http://dx.doi.org/10.1155/2020/5470739 |
| spellingShingle | Xiaoli Li Lianju Li Yuling Xing Tiantian Cheng Shaohui Ren Huijuan Ma Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies Journal of Diabetes Research |
| title | Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies |
| title_full | Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies |
| title_fullStr | Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies |
| title_full_unstemmed | Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies |
| title_short | Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies |
| title_sort | diabetes mellitus is associated with a lower risk of gout a meta analysis of observational studies |
| url | http://dx.doi.org/10.1155/2020/5470739 |
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