Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography

Abstract A major challenge in neuroscience is visualizing the structure of the human brain at different scales. Traditional histology reveals micro- and meso-scale brain features but suffers from staining variability, tissue damage, and distortion, which impedes accurate 3D reconstructions. The emer...

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Bibliographic Details
Main Authors: Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann C. McKee, Douglas L. Rosene, Hui Wang, Irving J. Bigio, David A. Boas, Lei Tian
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Light: Science & Applications
Online Access:https://doi.org/10.1038/s41377-024-01658-0
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