Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography
Abstract A major challenge in neuroscience is visualizing the structure of the human brain at different scales. Traditional histology reveals micro- and meso-scale brain features but suffers from staining variability, tissue damage, and distortion, which impedes accurate 3D reconstructions. The emer...
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Main Authors: | Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann C. McKee, Douglas L. Rosene, Hui Wang, Irving J. Bigio, David A. Boas, Lei Tian |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2025-01-01
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Series: | Light: Science & Applications |
Online Access: | https://doi.org/10.1038/s41377-024-01658-0 |
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