The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study
Brachial-ankle pulse wave velocity (baPWV) is a noninvasive clinical test that provides quantification for the stiffness of both the aorta and peripheral arteries by measuring the brachial and tibial arterial wave velocities. The temporal pattern of baPWV values during aging was investigated in this...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/3243135 |
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| author | Zhengli Tang Yuanyuan Lu Yiming Hao Robert Morris Di Kang Fang Wang Lin Fan Weijian Wang Yiqin Wang Feng Cheng |
| author_facet | Zhengli Tang Yuanyuan Lu Yiming Hao Robert Morris Di Kang Fang Wang Lin Fan Weijian Wang Yiqin Wang Feng Cheng |
| author_sort | Zhengli Tang |
| collection | DOAJ |
| description | Brachial-ankle pulse wave velocity (baPWV) is a noninvasive clinical test that provides quantification for the stiffness of both the aorta and peripheral arteries by measuring the brachial and tibial arterial wave velocities. The temporal pattern of baPWV values during aging was investigated in this paper. A gradual increase in baPWV with respect to age was observed, suggesting an increase in the stiffness of arterial vessels as age increases. The ΔbaPWV value, defined as the absolute value of the difference between bilateral baPWV, also showed a positive correlation with aging. Many underlying physiological conditions such as hyperlipidemia, hypertension, diabetes, and hyperglycemia have previously been shown to elevate baPWV and contribute to the decline of arterial function. The effect of factors including biological sex, blood pressure, and blood glucose levels on the baPWV temporal pattern were also investigated. Between the ages of 18 and 50, men in the study had significantly higher baPWV readings than females of comparable age on average. However, after the age of 50, mean baPWV values increased at a greater rate in females than in males. In addition, blood pressure and blood glucose were shown to be associated with baPWV values. The results will improve existing prediction models for future cardiovascular episodes induced by arterial hardening in different age groups. |
| format | Article |
| id | doaj-art-890dce9d16804440b8e30871fce15fbb |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-890dce9d16804440b8e30871fce15fbb2025-02-03T01:26:56ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/3243135The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional StudyZhengli Tang0Yuanyuan Lu1Yiming Hao2Robert Morris3Di Kang4Fang Wang5Lin Fan6Weijian Wang7Yiqin Wang8Feng Cheng9Shuguang Hospital Health Examination Center Affiliated with Shanghai University of Traditional Chinese MedicineDepartment of Biostatistics and EpidemiologyShanghai Key Laboratory of Health Identification and Assessment/Laboratory of Traditional Chinese Medicine Four Diagnostic InformationDepartment of Pharmaceutical SciencesDepartment of Biostatistics and EpidemiologyShuguang Hospital Health Examination Center Affiliated with Shanghai University of Traditional Chinese MedicineShuguang Hospital Health Examination Center Affiliated with Shanghai University of Traditional Chinese MedicineShuguang Hospital Health Examination Center Affiliated with Shanghai University of Traditional Chinese MedicineShanghai Key Laboratory of Health Identification and Assessment/Laboratory of Traditional Chinese Medicine Four Diagnostic InformationDepartment of Biostatistics and EpidemiologyBrachial-ankle pulse wave velocity (baPWV) is a noninvasive clinical test that provides quantification for the stiffness of both the aorta and peripheral arteries by measuring the brachial and tibial arterial wave velocities. The temporal pattern of baPWV values during aging was investigated in this paper. A gradual increase in baPWV with respect to age was observed, suggesting an increase in the stiffness of arterial vessels as age increases. The ΔbaPWV value, defined as the absolute value of the difference between bilateral baPWV, also showed a positive correlation with aging. Many underlying physiological conditions such as hyperlipidemia, hypertension, diabetes, and hyperglycemia have previously been shown to elevate baPWV and contribute to the decline of arterial function. The effect of factors including biological sex, blood pressure, and blood glucose levels on the baPWV temporal pattern were also investigated. Between the ages of 18 and 50, men in the study had significantly higher baPWV readings than females of comparable age on average. However, after the age of 50, mean baPWV values increased at a greater rate in females than in males. In addition, blood pressure and blood glucose were shown to be associated with baPWV values. The results will improve existing prediction models for future cardiovascular episodes induced by arterial hardening in different age groups.http://dx.doi.org/10.1155/2021/3243135 |
| spellingShingle | Zhengli Tang Yuanyuan Lu Yiming Hao Robert Morris Di Kang Fang Wang Lin Fan Weijian Wang Yiqin Wang Feng Cheng The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study Journal of Diabetes Research |
| title | The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study |
| title_full | The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study |
| title_fullStr | The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study |
| title_full_unstemmed | The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study |
| title_short | The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study |
| title_sort | temporal pattern of arterial stiffness during aging a large scale cross sectional study |
| url | http://dx.doi.org/10.1155/2021/3243135 |
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