Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria
Background. This study aimed to determine the pattern of drug susceptibility to first-line drugs among pulmonary TB patients in two hospitals in Calabar, Nigeria. Methods. This was a descriptive cross-sectional study carried out between February 2011 and April 2012. Sputum samples from consecutive T...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/235190 |
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| author | Akaninyene Otu Victor Umoh Abdulrazak Habib Soter Ameh Lovett Lawson Victor Ansa |
| author_facet | Akaninyene Otu Victor Umoh Abdulrazak Habib Soter Ameh Lovett Lawson Victor Ansa |
| author_sort | Akaninyene Otu |
| collection | DOAJ |
| description | Background. This study aimed to determine the pattern of drug susceptibility to first-line drugs among pulmonary TB patients in two hospitals in Calabar, Nigeria. Methods. This was a descriptive cross-sectional study carried out between February 2011 and April 2012. Sputum samples from consecutive TB patients in Calabar were subjected to culture on Lowenstein-Jensen (LJ) slopes followed by drug susceptibility testing (DST). The DST was performed on LJ medium by the proportion method. Results. Forty-two of the 100 Mycobacterium tuberculosis strains were found to be resistant to at least one drug. Resistance to only one drug (monoresistance) was found in 17 patients. No strains with monoresistance to rifampicin were found. Resistance to two drugs was found in 22 patients, while one patient was resistant to both three and four drugs. MDR TB was seen in 4% (4/100). The independent variables of HIV serology and sex were not significantly associated with resistance (P>0.05). Conclusion. There was a high prevalence of anti-TB drug resistance in Calabar. |
| format | Article |
| id | doaj-art-89039646161a49c799a11d14e642bceb |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-89039646161a49c799a11d14e642bceb2025-02-03T01:31:03ZengWileyPulmonary Medicine2090-18362090-18442013-01-01201310.1155/2013/235190235190Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, NigeriaAkaninyene Otu0Victor Umoh1Abdulrazak Habib2Soter Ameh3Lovett Lawson4Victor Ansa5Department of Internal Medicine, University of Calabar Teaching Hospital, PMB 1278, Cross River State, NigeriaDepartment of Internal Medicine, University of Calabar Teaching Hospital, PMB 1278, Cross River State, NigeriaDepartment of Medicine, Aminu Kano Teaching Hospital, PMB 3452, Kano, NigeriaDepartment of Community Medicine, University of Calabar Teaching Hospital, PMB 1278, Cross River State, NigeriaZankli Medical Centre, Plot 1021 Shehu YarAdua Way, Abuja, NigeriaDepartment of Internal Medicine, University of Calabar Teaching Hospital, PMB 1278, Cross River State, NigeriaBackground. This study aimed to determine the pattern of drug susceptibility to first-line drugs among pulmonary TB patients in two hospitals in Calabar, Nigeria. Methods. This was a descriptive cross-sectional study carried out between February 2011 and April 2012. Sputum samples from consecutive TB patients in Calabar were subjected to culture on Lowenstein-Jensen (LJ) slopes followed by drug susceptibility testing (DST). The DST was performed on LJ medium by the proportion method. Results. Forty-two of the 100 Mycobacterium tuberculosis strains were found to be resistant to at least one drug. Resistance to only one drug (monoresistance) was found in 17 patients. No strains with monoresistance to rifampicin were found. Resistance to two drugs was found in 22 patients, while one patient was resistant to both three and four drugs. MDR TB was seen in 4% (4/100). The independent variables of HIV serology and sex were not significantly associated with resistance (P>0.05). Conclusion. There was a high prevalence of anti-TB drug resistance in Calabar.http://dx.doi.org/10.1155/2013/235190 |
| spellingShingle | Akaninyene Otu Victor Umoh Abdulrazak Habib Soter Ameh Lovett Lawson Victor Ansa Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria Pulmonary Medicine |
| title | Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria |
| title_full | Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria |
| title_fullStr | Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria |
| title_full_unstemmed | Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria |
| title_short | Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria |
| title_sort | drug resistance among pulmonary tuberculosis patients in calabar nigeria |
| url | http://dx.doi.org/10.1155/2013/235190 |
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