Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters
The present study deals with the functional severity of a coronary artery stenosis assessed by the fractional flow reserve (FFR). The effects of different geometrical shapes of lesion on the diagnostic parameters are unknown. In this study, 3D computational simulation of blood flow in three differen...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/354946 |
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| author | Sarfaraz Kamangar Govindaraju Kalimuthu Irfan Anjum Badruddin A. Badarudin N. J. Salman Ahmed T. M. Yunus Khan |
| author_facet | Sarfaraz Kamangar Govindaraju Kalimuthu Irfan Anjum Badruddin A. Badarudin N. J. Salman Ahmed T. M. Yunus Khan |
| author_sort | Sarfaraz Kamangar |
| collection | DOAJ |
| description | The present study deals with the functional severity of a coronary artery stenosis assessed by the fractional flow reserve (FFR). The effects of different geometrical shapes of lesion on the diagnostic parameters are unknown. In this study, 3D computational simulation of blood flow in three different geometrical shapes of stenosis (triangular, elliptical, and trapezium) is considered in steady and transient conditions for 70% (moderate), 80% (intermediate), and 90% (severe) area stenosis (AS). For a given percentage AS, the variation of diagnostic parameters which are derived from pressure drop across the stenosis was found in three different geometrical shapes of stenosis and it was observed that FFR is higher in triangular shape and lower in trapezium shape. The pressure drop coefficient (CDP) was higher in trapezium shape and lower in triangular model whereas the LFC shows opposite trend. From the clinical perspective, the relationship between percentage AS and FFR is linear and inversely related in all the three models. A cut-off value of 0.75 for FFR was observed at 76.5% AS in trapezium model, 79.5% in elliptical model, and 82.7% AS for the triangular shaped model. The misinterpretation of the functional severity of the stenosis is in the region of 76.5%-82.7 % AS from different shapes of stenosis models. |
| format | Article |
| id | doaj-art-88faa0937b514681bac7c99b88b487a9 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-88faa0937b514681bac7c99b88b487a92025-02-03T06:14:12ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/354946354946Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic ParametersSarfaraz Kamangar0Govindaraju Kalimuthu1Irfan Anjum Badruddin2A. Badarudin3N. J. Salman Ahmed4T. M. Yunus Khan5Department of Mechanical Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Mechanical Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Mechanical Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Mechanical Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaFaculty of Engineering & Technology, Multimedia University, 75450 Bukit Beruang, Malacca, MalaysiaDepartment of Mechanical Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaThe present study deals with the functional severity of a coronary artery stenosis assessed by the fractional flow reserve (FFR). The effects of different geometrical shapes of lesion on the diagnostic parameters are unknown. In this study, 3D computational simulation of blood flow in three different geometrical shapes of stenosis (triangular, elliptical, and trapezium) is considered in steady and transient conditions for 70% (moderate), 80% (intermediate), and 90% (severe) area stenosis (AS). For a given percentage AS, the variation of diagnostic parameters which are derived from pressure drop across the stenosis was found in three different geometrical shapes of stenosis and it was observed that FFR is higher in triangular shape and lower in trapezium shape. The pressure drop coefficient (CDP) was higher in trapezium shape and lower in triangular model whereas the LFC shows opposite trend. From the clinical perspective, the relationship between percentage AS and FFR is linear and inversely related in all the three models. A cut-off value of 0.75 for FFR was observed at 76.5% AS in trapezium model, 79.5% in elliptical model, and 82.7% AS for the triangular shaped model. The misinterpretation of the functional severity of the stenosis is in the region of 76.5%-82.7 % AS from different shapes of stenosis models.http://dx.doi.org/10.1155/2014/354946 |
| spellingShingle | Sarfaraz Kamangar Govindaraju Kalimuthu Irfan Anjum Badruddin A. Badarudin N. J. Salman Ahmed T. M. Yunus Khan Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters The Scientific World Journal |
| title | Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters |
| title_full | Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters |
| title_fullStr | Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters |
| title_full_unstemmed | Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters |
| title_short | Numerical Investigation of the Effect of Stenosis Geometry on the Coronary Diagnostic Parameters |
| title_sort | numerical investigation of the effect of stenosis geometry on the coronary diagnostic parameters |
| url | http://dx.doi.org/10.1155/2014/354946 |
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