Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke
Stroke leads to significant disability in most patients, whereas cancer elevates the occurrence of stroke. The incidence of cancer-associated stroke (CAS) is projected to rise as a result of improvements in cancer therapies. Various forms of cancer have been demonstrated to be linked to ischemic str...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2079-7737/14/1/50 |
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| author | Surajit Hansda Hiranmoy Das |
| author_facet | Surajit Hansda Hiranmoy Das |
| author_sort | Surajit Hansda |
| collection | DOAJ |
| description | Stroke leads to significant disability in most patients, whereas cancer elevates the occurrence of stroke. The incidence of cancer-associated stroke (CAS) is projected to rise as a result of improvements in cancer therapies. Various forms of cancer have been demonstrated to be linked to ischemic stroke. Cancer might influence stroke pathophysiology either directly or through coagulation that creates a hypercoagulative state, in addition to infections. Treatment methods for cancer, including chemotherapy, radiotherapy, and surgery, have all been demonstrated to increase the risk of stroke as well. This review discusses the subtypes, epidemiology, pathophysiology, mechanisms of stroke within cancer patients, biomarkers, and signaling pathways of stroke in cancer while providing vital information on the involved transcription factors, treatment, and management of patients with cancer-associated ischemic stroke. Atherosclerosis, extracellular vesicles (EVs), and signaling biomolecules can also affect CAS. Overall, stroke is a significant and not uncommon complication of cancer, and there is an immediate demand for neurologists and oncologists to create strategies for screening and preventing strokes in cancer patients. |
| format | Article |
| id | doaj-art-88f78193298c43a4bbc0f47602ee9383 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-88f78193298c43a4bbc0f47602ee93832025-01-24T13:23:26ZengMDPI AGBiology2079-77372025-01-011415010.3390/biology14010050Insights into Cancer-Associated Thrombosis Leading Towards Ischemic StrokeSurajit Hansda0Hiranmoy Das1Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USADepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USAStroke leads to significant disability in most patients, whereas cancer elevates the occurrence of stroke. The incidence of cancer-associated stroke (CAS) is projected to rise as a result of improvements in cancer therapies. Various forms of cancer have been demonstrated to be linked to ischemic stroke. Cancer might influence stroke pathophysiology either directly or through coagulation that creates a hypercoagulative state, in addition to infections. Treatment methods for cancer, including chemotherapy, radiotherapy, and surgery, have all been demonstrated to increase the risk of stroke as well. This review discusses the subtypes, epidemiology, pathophysiology, mechanisms of stroke within cancer patients, biomarkers, and signaling pathways of stroke in cancer while providing vital information on the involved transcription factors, treatment, and management of patients with cancer-associated ischemic stroke. Atherosclerosis, extracellular vesicles (EVs), and signaling biomolecules can also affect CAS. Overall, stroke is a significant and not uncommon complication of cancer, and there is an immediate demand for neurologists and oncologists to create strategies for screening and preventing strokes in cancer patients.https://www.mdpi.com/2079-7737/14/1/50cancer-associated strokecancerischemic strokethrombosiscoagulopathy |
| spellingShingle | Surajit Hansda Hiranmoy Das Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke Biology cancer-associated stroke cancer ischemic stroke thrombosis coagulopathy |
| title | Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke |
| title_full | Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke |
| title_fullStr | Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke |
| title_full_unstemmed | Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke |
| title_short | Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke |
| title_sort | insights into cancer associated thrombosis leading towards ischemic stroke |
| topic | cancer-associated stroke cancer ischemic stroke thrombosis coagulopathy |
| url | https://www.mdpi.com/2079-7737/14/1/50 |
| work_keys_str_mv | AT surajithansda insightsintocancerassociatedthrombosisleadingtowardsischemicstroke AT hiranmoydas insightsintocancerassociatedthrombosisleadingtowardsischemicstroke |