A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

Abstract How SARS-CoV-2 Omicron evolved remains obscure. T492I, an Omicron-specific mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances viral replication and alters nonstructural protein cleavage, inferring potentials to drive evolution. Through evolve-and-resequence experime...

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Main Authors: Xiaoyuan Lin, Zhou Sha, Chunlin Zhang, Julia M. Adler, Ricardo Martin Vidal, Christine Langner, Beibei Fu, Yan Xiong, Meng Tan, Chen Jiang, Hao Zeng, Xiaokai Zhang, Qian Li, Jingmin Yan, Xiaoxue Lu, Shiwei Wang, Xuhu Mao, Dusan Kunec, Jakob Trimpert, Haibo Wu, Quanming Zou, Zhenglin Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62300-0
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