Targeting Toll-Like Receptors for Treatment of SLE
Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/498980 |
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| _version_ | 1832550014427070464 |
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| author | Christopher G. Horton Zi-jian Pan A. Darise Farris |
| author_facet | Christopher G. Horton Zi-jian Pan A. Darise Farris |
| author_sort | Christopher G. Horton |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. Activation of these TLRs results in the production of inflammatory cytokines and type I interferon. Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases. Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity. |
| format | Article |
| id | doaj-art-88dfa4310ff3477689bc83b4a15738d6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-88dfa4310ff3477689bc83b4a15738d62025-02-03T06:08:00ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/498980498980Targeting Toll-Like Receptors for Treatment of SLEChristopher G. Horton0Zi-jian Pan1A. Darise Farris2Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAArthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USADepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAToll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. Activation of these TLRs results in the production of inflammatory cytokines and type I interferon. Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases. Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity.http://dx.doi.org/10.1155/2010/498980 |
| spellingShingle | Christopher G. Horton Zi-jian Pan A. Darise Farris Targeting Toll-Like Receptors for Treatment of SLE Mediators of Inflammation |
| title | Targeting Toll-Like Receptors for Treatment of SLE |
| title_full | Targeting Toll-Like Receptors for Treatment of SLE |
| title_fullStr | Targeting Toll-Like Receptors for Treatment of SLE |
| title_full_unstemmed | Targeting Toll-Like Receptors for Treatment of SLE |
| title_short | Targeting Toll-Like Receptors for Treatment of SLE |
| title_sort | targeting toll like receptors for treatment of sle |
| url | http://dx.doi.org/10.1155/2010/498980 |
| work_keys_str_mv | AT christopherghorton targetingtolllikereceptorsfortreatmentofsle AT zijianpan targetingtolllikereceptorsfortreatmentofsle AT adarisefarris targetingtolllikereceptorsfortreatmentofsle |