Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma

Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma

ABSTRACT Background 7‐Hydroxymethotrexate (7‐OHMTX) is the main metabolite in plasma following high‐dose MTX (HD‐MTX), which may result in activity and toxicity of the MTX. Moreover, 7‐OHMTX could produce crystalline‐like deposits within the renal tubules under acidic conditions or induce renal infl...

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Bibliographic Details
Main Authors:	Hao Bing, Yi Ma, Jiamin Xu, Qixian Ling, Yanlong Duan, Libo Zhao
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	Cancer Medicine
Subjects:	methotrexate nephrotoxicity peak concentration population pharmacokinetics
Online Access:	https://doi.org/10.1002/cam4.70516
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