Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma
ABSTRACT Background 7‐Hydroxymethotrexate (7‐OHMTX) is the main metabolite in plasma following high‐dose MTX (HD‐MTX), which may result in activity and toxicity of the MTX. Moreover, 7‐OHMTX could produce crystalline‐like deposits within the renal tubules under acidic conditions or induce renal infl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.70516 |
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