Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes
A clear relationship between diabetes and cardiovascular disease has been established for decades. Despite this, the mechanisms by which diabetes contributes to plaque formation remain in question. Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/569654 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550795140136960 |
|---|---|
| author | Steven Daniel Funk Arif Yurdagul A. Wayne Orr |
| author_facet | Steven Daniel Funk Arif Yurdagul A. Wayne Orr |
| author_sort | Steven Daniel Funk |
| collection | DOAJ |
| description | A clear relationship between diabetes and cardiovascular disease has been established for decades. Despite this, the mechanisms by which diabetes contributes to plaque formation remain in question. Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic syndrome show proatherosclerotic effects independent of underlying diabetes. However, the hyperglycemia that defines the diabetic condition independently affects atherogenesis in cell culture systems, animal models, and human patients. Endothelial cell biology plays a central role in atherosclerotic plaque formation regulating vessel permeability, inflammation, and thrombosis. The current paper highlights the mechanisms by which hyperglycemia affects endothelial cell biology to promote plaque formation. |
| format | Article |
| id | doaj-art-88d94bb0eb134c35ad8e635564570609 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-88d94bb0eb134c35ad8e6355645706092025-02-03T06:05:47ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/569654569654Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 DiabetesSteven Daniel Funk0Arif Yurdagul1A. Wayne Orr2Departments of Cell Biology and Anatomy and Pathology, LSU Health Sciences Center, Shreveport, LA 71130, USADepartments of Cell Biology and Anatomy and Pathology, LSU Health Sciences Center, Shreveport, LA 71130, USADepartments of Cell Biology and Anatomy and Pathology, LSU Health Sciences Center, Shreveport, LA 71130, USAA clear relationship between diabetes and cardiovascular disease has been established for decades. Despite this, the mechanisms by which diabetes contributes to plaque formation remain in question. Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic syndrome show proatherosclerotic effects independent of underlying diabetes. However, the hyperglycemia that defines the diabetic condition independently affects atherogenesis in cell culture systems, animal models, and human patients. Endothelial cell biology plays a central role in atherosclerotic plaque formation regulating vessel permeability, inflammation, and thrombosis. The current paper highlights the mechanisms by which hyperglycemia affects endothelial cell biology to promote plaque formation.http://dx.doi.org/10.1155/2012/569654 |
| spellingShingle | Steven Daniel Funk Arif Yurdagul A. Wayne Orr Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes International Journal of Vascular Medicine |
| title | Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes |
| title_full | Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes |
| title_fullStr | Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes |
| title_full_unstemmed | Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes |
| title_short | Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes |
| title_sort | hyperglycemia and endothelial dysfunction in atherosclerosis lessons from type 1 diabetes |
| url | http://dx.doi.org/10.1155/2012/569654 |
| work_keys_str_mv | AT stevendanielfunk hyperglycemiaandendothelialdysfunctioninatherosclerosislessonsfromtype1diabetes AT arifyurdagul hyperglycemiaandendothelialdysfunctioninatherosclerosislessonsfromtype1diabetes AT awayneorr hyperglycemiaandendothelialdysfunctioninatherosclerosislessonsfromtype1diabetes |