Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review
Objective: To investigate the prevalence, mechanisms, and trends of knockdown resistance (kdr) in Anopheles (An.) culicifacies and its impact on the efficacy of organochlorine and other insecticides. Methods: A systematic review was conducted based on PRISMA guidelines, extracting data from biooan.o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/apjtm.apjtm_26_24 |
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| author | Ebrahim Abbasi Salman Daliri Shokrollah Mohseni Aman Allah Zamani Noorbakhsh Alivand Mohammad Djaefar Moemenbellah-Fard |
| author_facet | Ebrahim Abbasi Salman Daliri Shokrollah Mohseni Aman Allah Zamani Noorbakhsh Alivand Mohammad Djaefar Moemenbellah-Fard |
| author_sort | Ebrahim Abbasi |
| collection | DOAJ |
| description | Objective:
To investigate the prevalence, mechanisms, and trends of knockdown resistance (kdr) in Anopheles (An.) culicifacies and its impact on the efficacy of organochlorine and other insecticides.
Methods:
A systematic review was conducted based on PRISMA guidelines, extracting data from biooan.org, Embase, ProQuest, PubMed, Scopus, and Web of Science without a time limit until the end of 2022. Articles meeting the inclusion criteria were assessed using the STROBE checklist. Data on kdr mutations, insecticide resistance, and effectiveness were analyzed across eight selected studies from various regions.
Results:
The review revealed widespread kdr-mediated resistance in An. culicifacies, primarily against dichloro-diphenyl-trichloroethane (DDT), persisting even decades after discontinued use. Key kdr mutations, including L1014F and L1014S, were identified. Resistance to deltamethrin was less stable, with increased sensitivity observed after short-term discontinuation. The findings underscore the vector's sustained resistance to organochlorine insecticides and relative sensitivity to pyrethroids.
Conclusions:
Stable kdr resistance in An. culicifacies to organochlorine insecticides highlights the need for periodic susceptibility assessments and strategic rotation or combination of insecticides to combat malaria effectively and prevent the development of resistance. |
| format | Article |
| id | doaj-art-88cffd1f14f2439380269a0654cbe470 |
| institution | Kabale University |
| issn | 2352-4146 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj-art-88cffd1f14f2439380269a0654cbe4702025-02-06T04:59:52ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462025-01-011813910.4103/apjtm.apjtm_26_24Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic reviewEbrahim AbbasiSalman DaliriShokrollah MohseniAman Allah ZamaniNoorbakhsh AlivandMohammad Djaefar Moemenbellah-FardObjective: To investigate the prevalence, mechanisms, and trends of knockdown resistance (kdr) in Anopheles (An.) culicifacies and its impact on the efficacy of organochlorine and other insecticides. Methods: A systematic review was conducted based on PRISMA guidelines, extracting data from biooan.org, Embase, ProQuest, PubMed, Scopus, and Web of Science without a time limit until the end of 2022. Articles meeting the inclusion criteria were assessed using the STROBE checklist. Data on kdr mutations, insecticide resistance, and effectiveness were analyzed across eight selected studies from various regions. Results: The review revealed widespread kdr-mediated resistance in An. culicifacies, primarily against dichloro-diphenyl-trichloroethane (DDT), persisting even decades after discontinued use. Key kdr mutations, including L1014F and L1014S, were identified. Resistance to deltamethrin was less stable, with increased sensitivity observed after short-term discontinuation. The findings underscore the vector's sustained resistance to organochlorine insecticides and relative sensitivity to pyrethroids. Conclusions: Stable kdr resistance in An. culicifacies to organochlorine insecticides highlights the need for periodic susceptibility assessments and strategic rotation or combination of insecticides to combat malaria effectively and prevent the development of resistance.https://journals.lww.com/10.4103/apjtm.apjtm_26_24knockdown resistance (kdr)organochlorinemosquito-borne diseasesanopheles culicifaciessystematic review |
| spellingShingle | Ebrahim Abbasi Salman Daliri Shokrollah Mohseni Aman Allah Zamani Noorbakhsh Alivand Mohammad Djaefar Moemenbellah-Fard Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review Asian Pacific Journal of Tropical Medicine knockdown resistance (kdr) organochlorine mosquito-borne diseases anopheles culicifacies systematic review |
| title | Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review |
| title_full | Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review |
| title_fullStr | Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review |
| title_full_unstemmed | Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review |
| title_short | Knockdown resistance associated organochlorine resistance in mosquito–borne diseases (Anopheles culicifacies): A systematic review |
| title_sort | knockdown resistance associated organochlorine resistance in mosquito borne diseases anopheles culicifacies a systematic review |
| topic | knockdown resistance (kdr) organochlorine mosquito-borne diseases anopheles culicifacies systematic review |
| url | https://journals.lww.com/10.4103/apjtm.apjtm_26_24 |
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