GC–MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients

GC–MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients

Abstract Metformin (N,N-dimethylbiguanide), an inhibitor of gluconeogenesis and insulin sensitizer, is widely used for the treatment of type 2 diabetes. In some patients with renal insufficiency, metformin can accumulate and cause lactic acidosis, known as metformin-associated lactic acidosis (MALA,...

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Bibliographic Details
Main Authors: Svetlana Baskal, Rene A. Posma, Alexander Bollenbach, Willem Dieperink, Stephan J. L. Bakker, Maarten W. Nijsten, Daan J. Touw, Dimitrios Tsikas
Format: Article
Language:English
Published: Springer 2024-03-01
Series:Amino Acids
Subjects:
Amino acids
BMD
Dialysis
GC–MS
4-Hydroxyproline
Intoxication
Online Access:https://doi.org/10.1007/s00726-024-03383-9
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