Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury

Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury

Abstract Previous work indicates that SARS-CoV-2 virus entry proteins angiotensin-converting enzyme 2 (ACE-2) and the cell surface transmembrane protease serine 2 (TMPRSS-2) are regulated by sex hormones. However, clinical studies addressing this association have yielded conflicting results. We soug...

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Bibliographic Details
Main Authors: Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikail, Alexander Meisel, Achi Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-03181-3
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