Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain
Introduction Current treatments for chronic musculoskeletal (MSK) pain are suboptimal. Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approa...
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| Format: | Article |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e061548.full |
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| author | Fiona Campbell Jennifer Stinson Sara E Williams Christopher D King Laura Simons Massieh Moayedi Robert C Coghill Martin S Angst Nima Aghaeepour Brice Gaudilliere Marina López-Solà Marie-Eve Hoeppli Emma Biggs Ed Ganio Kenneth R Goldschneider Danielle Ruskin Elliot J Krane Suellen Walker Gillian Rush Marissa Heirich |
| author_facet | Fiona Campbell Jennifer Stinson Sara E Williams Christopher D King Laura Simons Massieh Moayedi Robert C Coghill Martin S Angst Nima Aghaeepour Brice Gaudilliere Marina López-Solà Marie-Eve Hoeppli Emma Biggs Ed Ganio Kenneth R Goldschneider Danielle Ruskin Elliot J Krane Suellen Walker Gillian Rush Marissa Heirich |
| author_sort | Fiona Campbell |
| collection | DOAJ |
| description | Introduction Current treatments for chronic musculoskeletal (MSK) pain are suboptimal. Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approaches that benefit all patients. Given that chronic pain is a biopsychosocial process, this study aims to discover and validate a robust prognostic signature that measures across multiple dimensions in the same adolescent patient cohort with a computational analysis pipeline. This will facilitate risk stratification in adolescent patients with chronic MSK pain and more resourceful allocation of patients to costly and potentially burdensome multidisciplinary pain treatment approaches.Methods and analysis Here we describe a multi-institutional effort to collect, curate and analyse a high dimensional data set including epidemiological, psychometric, quantitative sensory, brain imaging and biological information collected over the course of 12 months. The aim of this effort is to derive a multivariate model with strong prognostic power regarding the clinical course of adolescent MSK pain and function.Ethics and dissemination The study complies with the National Institutes of Health policy on the use of a single internal review board (sIRB) for multisite research, with Cincinnati Children’s Hospital Medical Center Review Board as the reviewing IRB. Stanford’s IRB is a relying IRB within the sIRB. As foreign institutions, the University of Toronto and The Hospital for Sick Children (SickKids) are overseen by their respective ethics boards. All participants provide signed informed consent. We are committed to open-access publication, so that patients, clinicians and scientists have access to the study data and the signature(s) derived. After findings are published, we will upload a limited data set for sharing with other investigators on applicable repositories.Trial registration number NCT04285112. |
| format | Article |
| id | doaj-art-88c3e685db664d75af24b1e25172c296 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-88c3e685db664d75af24b1e25172c2962025-01-28T13:25:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2022-061548Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal painFiona Campbell0Jennifer Stinson1Sara E Williams2Christopher D King3Laura Simons4Massieh Moayedi5Robert C Coghill6Martin S Angst7Nima Aghaeepour8Brice Gaudilliere9Marina López-Solà10Marie-Eve Hoeppli11Emma Biggs12Ed Ganio13Kenneth R Goldschneider14Danielle Ruskin15Elliot J Krane16Suellen Walker17Gillian Rush18Marissa Heirich19AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TGChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, CanadaPediatric Pain Research Center, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USACentre for Multimodal Sensorimotor and Pain Research, University of Toronto Faculty of Dentistry, Toronto, Ontario, CanadaDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USASerra Hunter Programme, Department of Medicine, University of Barcelona, Barcelona, SpainDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USAPediatric Pain Research Center (PPRC), Cincinnati Children`s Hospital Medical Center, Cincinnati, Ohio, USADepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USADevelopmental Neurosciences Department, UCL GOS Institute of Child Health, UCL, London, UKDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USAIntroduction Current treatments for chronic musculoskeletal (MSK) pain are suboptimal. Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approaches that benefit all patients. Given that chronic pain is a biopsychosocial process, this study aims to discover and validate a robust prognostic signature that measures across multiple dimensions in the same adolescent patient cohort with a computational analysis pipeline. This will facilitate risk stratification in adolescent patients with chronic MSK pain and more resourceful allocation of patients to costly and potentially burdensome multidisciplinary pain treatment approaches.Methods and analysis Here we describe a multi-institutional effort to collect, curate and analyse a high dimensional data set including epidemiological, psychometric, quantitative sensory, brain imaging and biological information collected over the course of 12 months. The aim of this effort is to derive a multivariate model with strong prognostic power regarding the clinical course of adolescent MSK pain and function.Ethics and dissemination The study complies with the National Institutes of Health policy on the use of a single internal review board (sIRB) for multisite research, with Cincinnati Children’s Hospital Medical Center Review Board as the reviewing IRB. Stanford’s IRB is a relying IRB within the sIRB. As foreign institutions, the University of Toronto and The Hospital for Sick Children (SickKids) are overseen by their respective ethics boards. All participants provide signed informed consent. We are committed to open-access publication, so that patients, clinicians and scientists have access to the study data and the signature(s) derived. After findings are published, we will upload a limited data set for sharing with other investigators on applicable repositories.Trial registration number NCT04285112.https://bmjopen.bmj.com/content/12/6/e061548.full |
| spellingShingle | Fiona Campbell Jennifer Stinson Sara E Williams Christopher D King Laura Simons Massieh Moayedi Robert C Coghill Martin S Angst Nima Aghaeepour Brice Gaudilliere Marina López-Solà Marie-Eve Hoeppli Emma Biggs Ed Ganio Kenneth R Goldschneider Danielle Ruskin Elliot J Krane Suellen Walker Gillian Rush Marissa Heirich Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain BMJ Open |
| title | Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain |
| title_full | Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain |
| title_fullStr | Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain |
| title_full_unstemmed | Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain |
| title_short | Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain |
| title_sort | signature for pain recovery in teens sprint protocol for a multisite prospective signature study in chronic musculoskeletal pain |
| url | https://bmjopen.bmj.com/content/12/6/e061548.full |
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