The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats
Background: Natural product active ingredients are currently being studied rigorously worldwide and offer a viable substitute for traditional immunotherapy for various medical disorders. Aim: The objective of the study was to investigate the immunostimulatory properties of fucoidan in albino Wist...
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| Format: | Article |
| Language: | English |
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Tripoli University
2024-08-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/?mno=194485 |
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| author | Rochmah Kurnijasanti Giftania Wardani Muhammad Rais Mustafa Sri Agus Sudjarwo |
| author_facet | Rochmah Kurnijasanti Giftania Wardani Muhammad Rais Mustafa Sri Agus Sudjarwo |
| author_sort | Rochmah Kurnijasanti |
| collection | DOAJ |
| description | Background:
Natural product active ingredients are currently being studied rigorously worldwide and offer a viable substitute for traditional immunotherapy for various medical disorders.
Aim:
The objective of the study was to investigate the immunostimulatory properties of fucoidan in albino Wistar rats.
Methods:
For the current study, forty rats were divided into five groups of rats that were used in good condition. In-vivo experiments of fucoidan were carried out in Wistar albino rats, such as the cyclophosphamide-caused myelosuppression, the delayed-type hypersensitivity (DTH) response, the phagocytic activity, the haemagglutinating antibody (HA) titer, and the neutrophil adhesion test.
Results:
The phagocytic index increased significantly in response to Fucoidan in a dose-dependent manner, as well as enhanced DTH reaction, and HA titer caused by sheep red blood cells sheep red blood cells. Additionally, fucoidan decreased myelosuppression in rats after cyclophosphamide treatment and enhanced neutrophil adhesion with nylon f iber.
Conclusion:
These findings imply that fucoidan has immunostimulant properties and could potentially utilised to treat immune-depression diseases. [Open Vet J 2024; 14(8.000): 1794-1800] |
| format | Article |
| id | doaj-art-88a10ce534224cdea8398e5d44bc57bd |
| institution | OA Journals |
| issn | 2226-4485 2218-6050 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj-art-88a10ce534224cdea8398e5d44bc57bd2025-08-20T01:47:36ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502024-08-011481794180010.5455/OVJ.2024.v14.i8.7194485The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar ratsRochmah Kurnijasanti0Giftania Wardani1Muhammad Rais Mustafa2Sri Agus Sudjarwo3Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia Program Study of Pharmacy, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaBackground: Natural product active ingredients are currently being studied rigorously worldwide and offer a viable substitute for traditional immunotherapy for various medical disorders. Aim: The objective of the study was to investigate the immunostimulatory properties of fucoidan in albino Wistar rats. Methods: For the current study, forty rats were divided into five groups of rats that were used in good condition. In-vivo experiments of fucoidan were carried out in Wistar albino rats, such as the cyclophosphamide-caused myelosuppression, the delayed-type hypersensitivity (DTH) response, the phagocytic activity, the haemagglutinating antibody (HA) titer, and the neutrophil adhesion test. Results: The phagocytic index increased significantly in response to Fucoidan in a dose-dependent manner, as well as enhanced DTH reaction, and HA titer caused by sheep red blood cells sheep red blood cells. Additionally, fucoidan decreased myelosuppression in rats after cyclophosphamide treatment and enhanced neutrophil adhesion with nylon f iber. Conclusion: These findings imply that fucoidan has immunostimulant properties and could potentially utilised to treat immune-depression diseases. [Open Vet J 2024; 14(8.000): 1794-1800]https://www.openveterinaryjournal.com/?mno=194485fucoidanimmunostimulanthumoral immune responsecellular immune response |
| spellingShingle | Rochmah Kurnijasanti Giftania Wardani Muhammad Rais Mustafa Sri Agus Sudjarwo The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats Open Veterinary Journal fucoidan immunostimulant humoral immune response cellular immune response |
| title | The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats |
| title_full | The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats |
| title_fullStr | The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats |
| title_full_unstemmed | The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats |
| title_short | The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats |
| title_sort | immunostimulatory effects of fucoidan on the cellular and humoral immune response in wistar rats |
| topic | fucoidan immunostimulant humoral immune response cellular immune response |
| url | https://www.openveterinaryjournal.com/?mno=194485 |
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