Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes
Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-g, and TNF-a...
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| Format: | Article |
| Language: | English |
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Sciendo
2015-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2015-0015 |
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| author | Lasek Witold Janyst Michał Wolny Rafał Zapała Łukasz Bocian Katarzyna Drela Nadzieja |
| author_facet | Lasek Witold Janyst Michał Wolny Rafał Zapała Łukasz Bocian Katarzyna Drela Nadzieja |
| author_sort | Lasek Witold |
| collection | DOAJ |
| description | Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-g, and TNF-a) or Th2 cells (IL-4, IL-5, and IL-10) were tested in human peripheral blood lymphocyte cultures stimulated with phytohemagglutinin (PHA). Inos enhanced TNF-a secretion significantly (in short-term - 24-hour, and prolonged term - 72-hour cultures) and IFN-g (in 72-hour cultures). Surprisingly, production of IL-10 by PHA-stimulated lymphocytes was suppressed by Inos in a dose-dependent manner in both 24-hour and 72-hour cultures. These results shed some light on immunomodulatory properties of Inos and suggest applicability of this agent in patients with a depressed function of the immune system. |
| format | Article |
| id | doaj-art-888c29c5f3704130b55f2d5ef37a29ad |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-888c29c5f3704130b55f2d5ef37a29ad2025-02-02T08:32:25ZengSciendoActa Pharmaceutica1846-95582015-06-0165217118010.1515/acph-2015-0015acph-2015-0015Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytesLasek Witold0Janyst Michał1Wolny Rafał2Zapała Łukasz3Bocian Katarzyna4Drela Nadzieja5Department of Immunology Centre of Biostructure Research Medical University of Warsaw Warsaw, PolandDepartment of Immunology Centre of Biostructure Research Medical University of Warsaw Warsaw, PolandDepartment of Immunology Centre of Biostructure Research Medical University of Warsaw Warsaw, PolandDepartment of Immunology Centre of Biostructure Research Medical University of Warsaw Warsaw, PolandDepartment of Immunology Faculty of Biology University of Warsaw, Warsaw, PolandDepartment of Immunology Faculty of Biology University of Warsaw, Warsaw, PolandInosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-g, and TNF-a) or Th2 cells (IL-4, IL-5, and IL-10) were tested in human peripheral blood lymphocyte cultures stimulated with phytohemagglutinin (PHA). Inos enhanced TNF-a secretion significantly (in short-term - 24-hour, and prolonged term - 72-hour cultures) and IFN-g (in 72-hour cultures). Surprisingly, production of IL-10 by PHA-stimulated lymphocytes was suppressed by Inos in a dose-dependent manner in both 24-hour and 72-hour cultures. These results shed some light on immunomodulatory properties of Inos and suggest applicability of this agent in patients with a depressed function of the immune system.https://doi.org/10.1515/acph-2015-0015inosine pranobeximmunomodulationcytokinesil-10 |
| spellingShingle | Lasek Witold Janyst Michał Wolny Rafał Zapała Łukasz Bocian Katarzyna Drela Nadzieja Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes Acta Pharmaceutica inosine pranobex immunomodulation cytokines il-10 |
| title | Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes |
| title_full | Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes |
| title_fullStr | Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes |
| title_full_unstemmed | Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes |
| title_short | Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes |
| title_sort | immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes |
| topic | inosine pranobex immunomodulation cytokines il-10 |
| url | https://doi.org/10.1515/acph-2015-0015 |
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