Iron Chelators in Treatment of Iron Overload
Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free rad...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2022/4911205 |
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| author | Sarina Entezari Seyedeh Mona Haghi Narges Norouzkhani Barsa Sahebnazar Fatemeh Vosoughian Diba Akbarzadeh Muhammad Islampanah Navid Naghsh Mohammad Abbasalizadeh Niloofar Deravi |
| author_facet | Sarina Entezari Seyedeh Mona Haghi Narges Norouzkhani Barsa Sahebnazar Fatemeh Vosoughian Diba Akbarzadeh Muhammad Islampanah Navid Naghsh Mohammad Abbasalizadeh Niloofar Deravi |
| author_sort | Sarina Entezari |
| collection | DOAJ |
| description | Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free radicals. In the past few decades, there has been a major improvement in the survival of patients who suffer from iron overload due to the application of iron chelation therapy in clinical practice. In clinical use, deferoxamine, deferiprone, and deferasirox are the three United States Food and Drug Administration-approved iron chelators. Each of these iron chelators is well known for the treatment of iron overload in various clinical conditions. Based on several up-to-date studies, this study explained iron overload and its clinical symptoms, introduced each of the above-mentioned iron chelators, and evaluated their advantages and disadvantages with an emphasis on combination therapy, which in recent studies seems a promising approach. In numerous clinical conditions, due to the lack of accurate indicators, choosing a standard approach for iron chelation therapy can be difficult; therefore, further studies on the issue are still required. This study aimed to introduce each of these iron chelators, combination therapy, usage doses, specific clinical applications, and their advantages, toxicity, and side effects. |
| format | Article |
| id | doaj-art-886f87c1a0524308a3c2dd3ecf253e71 |
| institution | Kabale University |
| issn | 1687-8205 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-886f87c1a0524308a3c2dd3ecf253e712025-02-03T01:22:27ZengWileyJournal of Toxicology1687-82052022-01-01202210.1155/2022/4911205Iron Chelators in Treatment of Iron OverloadSarina Entezari0Seyedeh Mona Haghi1Narges Norouzkhani2Barsa Sahebnazar3Fatemeh Vosoughian4Diba Akbarzadeh5Muhammad Islampanah6Navid Naghsh7Mohammad Abbasalizadeh8Niloofar Deravi9Student Research CommitteeStudent Research CommitteeDepartment of Medical InformaticsStudent Research CommitteeStudent Research CommitteeStudent Research CommitteeFaculty of MedicineDepartment of PharmacyFaculty of MedicineStudent Research CommitteePatients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free radicals. In the past few decades, there has been a major improvement in the survival of patients who suffer from iron overload due to the application of iron chelation therapy in clinical practice. In clinical use, deferoxamine, deferiprone, and deferasirox are the three United States Food and Drug Administration-approved iron chelators. Each of these iron chelators is well known for the treatment of iron overload in various clinical conditions. Based on several up-to-date studies, this study explained iron overload and its clinical symptoms, introduced each of the above-mentioned iron chelators, and evaluated their advantages and disadvantages with an emphasis on combination therapy, which in recent studies seems a promising approach. In numerous clinical conditions, due to the lack of accurate indicators, choosing a standard approach for iron chelation therapy can be difficult; therefore, further studies on the issue are still required. This study aimed to introduce each of these iron chelators, combination therapy, usage doses, specific clinical applications, and their advantages, toxicity, and side effects.http://dx.doi.org/10.1155/2022/4911205 |
| spellingShingle | Sarina Entezari Seyedeh Mona Haghi Narges Norouzkhani Barsa Sahebnazar Fatemeh Vosoughian Diba Akbarzadeh Muhammad Islampanah Navid Naghsh Mohammad Abbasalizadeh Niloofar Deravi Iron Chelators in Treatment of Iron Overload Journal of Toxicology |
| title | Iron Chelators in Treatment of Iron Overload |
| title_full | Iron Chelators in Treatment of Iron Overload |
| title_fullStr | Iron Chelators in Treatment of Iron Overload |
| title_full_unstemmed | Iron Chelators in Treatment of Iron Overload |
| title_short | Iron Chelators in Treatment of Iron Overload |
| title_sort | iron chelators in treatment of iron overload |
| url | http://dx.doi.org/10.1155/2022/4911205 |
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