Low-liver-accumulation lipid nanoparticles enhance the efficacy and safety of HPV therapeutic tumor vaccines

Low-liver-accumulation lipid nanoparticles enhance the efficacy and safety of HPV therapeutic tumor vaccines

Abstract Background Lipid nanoparticles (LNPs) hold significant potential in vaccine and cancer therapy, but conventional LNPs often cause hepatotoxicity and reduced efficacy due to liver accumulation. Methods LNP molecules with varying tail lengths were synthesized in vitro. Transfection efficiency...

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Bibliographic Details
Main Authors: Xiaodie Wang, Zhidan Tian, Meng Wang, Xiaoru Cai, Shuyan Yang, Jianyao Zeng, Yuan Fang, Xuesen Bai, Pei Wang, Yan Sun, Chuanxin Guo, Tao Liu, Qijun Qian
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
mRNA delivery
Lipid nanoparticles (LNPs)
Cancer immunotherapy
Hepatotoxicity mitigation
Online Access:https://doi.org/10.1186/s12967-025-06924-2
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