Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy
Inflammatory bowel disorders (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract (GIT). They pose significant treatment challenges due to their complex etiology. Current therapies focus on reducing inflammation bu...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004882 |
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| author | George Chigozie Njoku Cathal Patrick Forkan Fumie Mitani Soltysik Peter Lindberg Nejsum Flemming Pociot Reza Yarani |
| author_facet | George Chigozie Njoku Cathal Patrick Forkan Fumie Mitani Soltysik Peter Lindberg Nejsum Flemming Pociot Reza Yarani |
| author_sort | George Chigozie Njoku |
| collection | DOAJ |
| description | Inflammatory bowel disorders (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract (GIT). They pose significant treatment challenges due to their complex etiology. Current therapies focus on reducing inflammation but often prove inadequate, leading to a substantial need for novel approaches. Cell therapy looks promising, especially using mesenchymal stromal cells (MSCs) and their secretome, including extracellular vesicles (EVs). EVs are nano-sized vesicles that are non-replicating and carry bioactive molecules that modulate immune responses, promote tissue repair, can facilitate drug delivery and, therefore, hold great therapeutic promise. This review summarizes the role of EVs as a cell-free therapy for IBD, highlighting opportunities for further investigation and potential clinical applications. |
| format | Article |
| id | doaj-art-886d5469f17a4f17bb06f6a5fa319217 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-886d5469f17a4f17bb06f6a5fa3192172025-01-26T05:04:19ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-01454157Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapyGeorge Chigozie Njoku0Cathal Patrick Forkan1Fumie Mitani Soltysik2Peter Lindberg Nejsum3Flemming Pociot4Reza Yarani5Translational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Medical Biotechnology, University of Naples Federico II, Naples, Italy; Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, USATranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Pharmacy, Université Grenoble Alpes, FranceTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, DenmarkDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, DenmarkTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, DenmarkTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark; Corresponding author.Inflammatory bowel disorders (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract (GIT). They pose significant treatment challenges due to their complex etiology. Current therapies focus on reducing inflammation but often prove inadequate, leading to a substantial need for novel approaches. Cell therapy looks promising, especially using mesenchymal stromal cells (MSCs) and their secretome, including extracellular vesicles (EVs). EVs are nano-sized vesicles that are non-replicating and carry bioactive molecules that modulate immune responses, promote tissue repair, can facilitate drug delivery and, therefore, hold great therapeutic promise. This review summarizes the role of EVs as a cell-free therapy for IBD, highlighting opportunities for further investigation and potential clinical applications.http://www.sciencedirect.com/science/article/pii/S2452199X24004882Ulcerative colitisCrohn's diseaseMesenchymal stromal cellsExtracellular vesiclesImmunomodulationRegeneration |
| spellingShingle | George Chigozie Njoku Cathal Patrick Forkan Fumie Mitani Soltysik Peter Lindberg Nejsum Flemming Pociot Reza Yarani Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy Bioactive Materials Ulcerative colitis Crohn's disease Mesenchymal stromal cells Extracellular vesicles Immunomodulation Regeneration |
| title | Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy |
| title_full | Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy |
| title_fullStr | Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy |
| title_full_unstemmed | Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy |
| title_short | Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy |
| title_sort | unleashing the potential of extracellular vesicles for ulcerative colitis and crohn s disease therapy |
| topic | Ulcerative colitis Crohn's disease Mesenchymal stromal cells Extracellular vesicles Immunomodulation Regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004882 |
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