MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study
Blood pressure measurement is important in monitoring hypertension. However, blood pressure does not provide much information about renal condition in treated hypertension. This study aimed to evaluate renal oxygenation in hypertensive patients using T2* mapping. Subgroup analysis explored whether R...
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2025-01-01
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| author | Chun-Hung Liu Jeon-Hor Chen Antonio Carlos Westphalen Chun-Ming Chen Chih-Ping Chang Wei-Ching Lin |
| author_facet | Chun-Hung Liu Jeon-Hor Chen Antonio Carlos Westphalen Chun-Ming Chen Chih-Ping Chang Wei-Ching Lin |
| author_sort | Chun-Hung Liu |
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| description | Blood pressure measurement is important in monitoring hypertension. However, blood pressure does not provide much information about renal condition in treated hypertension. This study aimed to evaluate renal oxygenation in hypertensive patients using T2* mapping. Subgroup analysis explored whether R2* values can guide adjustments in antihypertensive treatment. A total of 140 consecutive subjects were recruited: 87 hypertensive subjects and 53 normotensive subjects. Hypertensive subjects were classified into non-medication (non-med), angiotensin II receptor blocker (ARB), and non-ARB-treated groups. Each group was divided into good and poor control subgroups based on blood pressure at enrollment. T2* mapping was utilized to assess renal cortical and medullary R2* values. After a 2-year follow-up, subjects were categorized into stable and unstable based on the need for treatment modifications. The unstable subgroup had higher medullary R2* values than the stable subgroup in all followed patients (<i>p</i> < 0.05). Additionally, the unstable merged non-med with ARB subgroup had higher medullary R2* values overall (<i>p</i> < 0.05) and within the good control subgroup (<i>p</i> < 0.05). Patients with stable hypertension, especially those with good control managed through lifestyle modifications or ARBs, exhibited lower renal medullary R2* values, suggesting higher renal oxygenation. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-886d475ceb3a4800851a666daf0b28472025-01-24T13:38:41ZengMDPI AGLife2075-17292025-01-011517310.3390/life15010073MR T2* Map to Predict Worsening Hypertension Control: A Preliminary StudyChun-Hung Liu0Jeon-Hor Chen1Antonio Carlos Westphalen2Chun-Ming Chen3Chih-Ping Chang4Wei-Ching Lin5Department of Medical Imaging, China Medical University Hospital, Taichung 40402, TaiwanDepartment of Radiology, E-Da Hospital and I-Shou University, Kaohsiung 82445, TaiwanDepartments of Radiology, Urology and Radiation Oncology, University of Washington, Seattle, WA 98195, USADepartment of Medical Imaging, China Medical University Hospital, Taichung 40402, TaiwanDepartment of Cardiology, China Medical University Hospital, Taichung 40402, TaiwanDepartment of Medical Imaging, China Medical University Hospital, Taichung 40402, TaiwanBlood pressure measurement is important in monitoring hypertension. However, blood pressure does not provide much information about renal condition in treated hypertension. This study aimed to evaluate renal oxygenation in hypertensive patients using T2* mapping. Subgroup analysis explored whether R2* values can guide adjustments in antihypertensive treatment. A total of 140 consecutive subjects were recruited: 87 hypertensive subjects and 53 normotensive subjects. Hypertensive subjects were classified into non-medication (non-med), angiotensin II receptor blocker (ARB), and non-ARB-treated groups. Each group was divided into good and poor control subgroups based on blood pressure at enrollment. T2* mapping was utilized to assess renal cortical and medullary R2* values. After a 2-year follow-up, subjects were categorized into stable and unstable based on the need for treatment modifications. The unstable subgroup had higher medullary R2* values than the stable subgroup in all followed patients (<i>p</i> < 0.05). Additionally, the unstable merged non-med with ARB subgroup had higher medullary R2* values overall (<i>p</i> < 0.05) and within the good control subgroup (<i>p</i> < 0.05). Patients with stable hypertension, especially those with good control managed through lifestyle modifications or ARBs, exhibited lower renal medullary R2* values, suggesting higher renal oxygenation.https://www.mdpi.com/2075-1729/15/1/73T2* mappinghypertensionblood pressureARBrenal oxygenation |
| spellingShingle | Chun-Hung Liu Jeon-Hor Chen Antonio Carlos Westphalen Chun-Ming Chen Chih-Ping Chang Wei-Ching Lin MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study Life T2* mapping hypertension blood pressure ARB renal oxygenation |
| title | MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study |
| title_full | MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study |
| title_fullStr | MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study |
| title_full_unstemmed | MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study |
| title_short | MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study |
| title_sort | mr t2 map to predict worsening hypertension control a preliminary study |
| topic | T2* mapping hypertension blood pressure ARB renal oxygenation |
| url | https://www.mdpi.com/2075-1729/15/1/73 |
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