Emerging role of extracellular microRNAs and lncRNAs
Abstract The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms. Importantly, these extracellular miRNAs and lncRNAs are promising noninvasive biomarkers for diagno...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2019-03-01
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| Series: | ExRNA |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41544-019-0012-2 |
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| _version_ | 1849251423852691456 |
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| author | Geyu Zhou Xi Chen |
| author_facet | Geyu Zhou Xi Chen |
| author_sort | Geyu Zhou |
| collection | DOAJ |
| description | Abstract The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms. Importantly, these extracellular miRNAs and lncRNAs are promising noninvasive biomarkers for diagnosis and prognosis of pathological status. Extracellular vesicles (EVs) are natural carriers of secreted extracellular miRNAs and lncRNAs. Although knowledge regarding the biologically relevant role of extracellular miRNAs is expanding, whether extracellular lncRNAs play a similar role remains incompletely understood. Here, we review the current knowledge regarding extracellular miRNAs and highlight a recent advance demonstrating that extracellular lncRNAs may also mediate cell-to-cell communication and other complicated biological processes. |
| format | Article |
| id | doaj-art-8867d2fc6ebf4386b12ac6b54055d76b |
| institution | Kabale University |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-8867d2fc6ebf4386b12ac6b54055d76b2025-08-20T03:56:58ZengELS Publishing (ELSP)ExRNA2398-00602019-03-01111610.1186/s41544-019-0012-2Emerging role of extracellular microRNAs and lncRNAsGeyu Zhou0Xi Chen1State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, Nanjing UniversityAbstract The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms. Importantly, these extracellular miRNAs and lncRNAs are promising noninvasive biomarkers for diagnosis and prognosis of pathological status. Extracellular vesicles (EVs) are natural carriers of secreted extracellular miRNAs and lncRNAs. Although knowledge regarding the biologically relevant role of extracellular miRNAs is expanding, whether extracellular lncRNAs play a similar role remains incompletely understood. Here, we review the current knowledge regarding extracellular miRNAs and highlight a recent advance demonstrating that extracellular lncRNAs may also mediate cell-to-cell communication and other complicated biological processes.http://link.springer.com/article/10.1186/s41544-019-0012-2ExosomemicroRNAlncRNA |
| spellingShingle | Geyu Zhou Xi Chen Emerging role of extracellular microRNAs and lncRNAs ExRNA Exosome microRNA lncRNA |
| title | Emerging role of extracellular microRNAs and lncRNAs |
| title_full | Emerging role of extracellular microRNAs and lncRNAs |
| title_fullStr | Emerging role of extracellular microRNAs and lncRNAs |
| title_full_unstemmed | Emerging role of extracellular microRNAs and lncRNAs |
| title_short | Emerging role of extracellular microRNAs and lncRNAs |
| title_sort | emerging role of extracellular micrornas and lncrnas |
| topic | Exosome microRNA lncRNA |
| url | http://link.springer.com/article/10.1186/s41544-019-0012-2 |
| work_keys_str_mv | AT geyuzhou emergingroleofextracellularmicrornasandlncrnas AT xichen emergingroleofextracellularmicrornasandlncrnas |