Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model
PM2.5 and arsenic are two of the most hazardous substances for humans that coexist worldwide. Independently, they might cause multiple organ damage. However, the combined effect of PM2.5 and arsenic has not been studied. Here, we used an animal model of simultaneous exposure to arsenic and PM2.5. Ad...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2024/5391316 |
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| author | Cesar Rivas-Santiago Maria Gallegos-Bañuelos Irving Trejo-Ramos Nancy Solís-Torres Raúl Quintana-Belmares Noé Macías-Segura Héctor Gutiérrez-Bañuelos Lorena Troncoso-Vazquez Bruno Rivas-Santiago Irma Gonzalez-Curiel |
| author_facet | Cesar Rivas-Santiago Maria Gallegos-Bañuelos Irving Trejo-Ramos Nancy Solís-Torres Raúl Quintana-Belmares Noé Macías-Segura Héctor Gutiérrez-Bañuelos Lorena Troncoso-Vazquez Bruno Rivas-Santiago Irma Gonzalez-Curiel |
| author_sort | Cesar Rivas-Santiago |
| collection | DOAJ |
| description | PM2.5 and arsenic are two of the most hazardous substances for humans that coexist worldwide. Independently, they might cause multiple organ damage. However, the combined effect of PM2.5 and arsenic has not been studied. Here, we used an animal model of simultaneous exposure to arsenic and PM2.5. Adult Wistar rats were exposed to PM2.5, As, or PM2.5 + As and their corresponding control groups. After 7, 14, and 28 days of exposure, the animals were euthanized and serum, lungs, kidneys, and hearts were collected. Analysis performed showed high levels of lung inflammation in all experimental groups, with an additive effect in the coexposed group. Besides, we observed cartilaginous metaplasia in the hearts of all exposed animals. The levels of creatine kinase, CK-MB, and lactate dehydrogenase increased in experimental groups. Tissue alterations might be related to oxidative stress through increased GPx and NADPH oxidase activity. The findings of this study suggest that exposure to arsenic, PM2.5, or coexposure induces high levels of oxidative stress, which might be associated with lung inflammation and heart damage. These findings highlight the importance of reducing exposure to these pollutants to protect human health. |
| format | Article |
| id | doaj-art-886445476e5846a4a6ca9de49b3ce45f |
| institution | Kabale University |
| issn | 1687-8205 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-886445476e5846a4a6ca9de49b3ce45f2025-02-03T07:23:24ZengWileyJournal of Toxicology1687-82052024-01-01202410.1155/2024/5391316Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine ModelCesar Rivas-Santiago0Maria Gallegos-Bañuelos1Irving Trejo-Ramos2Nancy Solís-Torres3Raúl Quintana-Belmares4Noé Macías-Segura5Héctor Gutiérrez-Bañuelos6Lorena Troncoso-Vazquez7Bruno Rivas-Santiago8Irma Gonzalez-Curiel9CONAHCYT-Academic Unit of Chemical SciencesSciences and Chemical TechnologySciences and Chemical TechnologyPharmacobiologyBasic ResearchService and Department of ImmunologyVeterinary Medicine and Zootechnics SchoolHistology LaboratoryBiomedical Research Unit-Zacatecas-IMSSSciences and Chemical TechnologyPM2.5 and arsenic are two of the most hazardous substances for humans that coexist worldwide. Independently, they might cause multiple organ damage. However, the combined effect of PM2.5 and arsenic has not been studied. Here, we used an animal model of simultaneous exposure to arsenic and PM2.5. Adult Wistar rats were exposed to PM2.5, As, or PM2.5 + As and their corresponding control groups. After 7, 14, and 28 days of exposure, the animals were euthanized and serum, lungs, kidneys, and hearts were collected. Analysis performed showed high levels of lung inflammation in all experimental groups, with an additive effect in the coexposed group. Besides, we observed cartilaginous metaplasia in the hearts of all exposed animals. The levels of creatine kinase, CK-MB, and lactate dehydrogenase increased in experimental groups. Tissue alterations might be related to oxidative stress through increased GPx and NADPH oxidase activity. The findings of this study suggest that exposure to arsenic, PM2.5, or coexposure induces high levels of oxidative stress, which might be associated with lung inflammation and heart damage. These findings highlight the importance of reducing exposure to these pollutants to protect human health.http://dx.doi.org/10.1155/2024/5391316 |
| spellingShingle | Cesar Rivas-Santiago Maria Gallegos-Bañuelos Irving Trejo-Ramos Nancy Solís-Torres Raúl Quintana-Belmares Noé Macías-Segura Héctor Gutiérrez-Bañuelos Lorena Troncoso-Vazquez Bruno Rivas-Santiago Irma Gonzalez-Curiel Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model Journal of Toxicology |
| title | Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model |
| title_full | Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model |
| title_fullStr | Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model |
| title_full_unstemmed | Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model |
| title_short | Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model |
| title_sort | adverse health effects of the long term simultaneous exposure to arsenic and particulate matter in a murine model |
| url | http://dx.doi.org/10.1155/2024/5391316 |
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