Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Aim. To evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM). Methods. A systematic literature search was performed in PubMed, EMBASE, Web of Science, and The Cochrane Library up to 4 September 2017. Pooled standardized mean differences (SMD) and 95% co...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1985026 |
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| _version_ | 1832567382000795648 |
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| author | Zhongwei Zhou Hongmei Chen Mingzhong Sun Huixiang Ju |
| author_facet | Zhongwei Zhou Hongmei Chen Mingzhong Sun Huixiang Ju |
| author_sort | Zhongwei Zhou |
| collection | DOAJ |
| description | Aim. To evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM). Methods. A systematic literature search was performed in PubMed, EMBASE, Web of Science, and The Cochrane Library up to 4 September 2017. Pooled standardized mean differences (SMD) and 95% confidence interval (CI) were calculated using a random-effect model. Results. Nineteen studies comprising 1361 GDM patients and 1911 normal pregnant women were included. MPV was increased in GDM patients when compared with healthy pregnant women (SMD: 0.79; 95% CI: 0.43–1.16; P<0.001). Subgroup analyses revealed that such trend was consistent in the third-trimester (SMD: 1.35; 95% CI: 0.72–1.98), Turkish (SMD: 0.81; 95% CI: 0.43–1.19), and Italian (SMD: 2.78; 95% CI: 2.22–3.34) patients with GDM and the patients diagnosed based on Carpenter and Coustan criteria (SMD: 1.04; 95% CI: 0.42–1.65). Significantly higher MPV also were observed within cross-sectional studies (SMD: 0.99; 95% CI: 0.49–1.49). Remarkable between-study heterogeneity and potential publication bias were observed in this meta-analysis; however, sensitivity analysis indicated that the results were not unduly influenced by any single study. Conclusions. GDM patients are accompanied by increased MPV, strengthening the clinical evidence that MPV may be a predictive marker for GDM. |
| format | Article |
| id | doaj-art-8863c55ae08441018e7bd984fb086fd8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8863c55ae08441018e7bd984fb086fd82025-02-03T01:01:39ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/19850261985026Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-AnalysisZhongwei Zhou0Hongmei Chen1Mingzhong Sun2Huixiang Ju3Department of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaAim. To evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM). Methods. A systematic literature search was performed in PubMed, EMBASE, Web of Science, and The Cochrane Library up to 4 September 2017. Pooled standardized mean differences (SMD) and 95% confidence interval (CI) were calculated using a random-effect model. Results. Nineteen studies comprising 1361 GDM patients and 1911 normal pregnant women were included. MPV was increased in GDM patients when compared with healthy pregnant women (SMD: 0.79; 95% CI: 0.43–1.16; P<0.001). Subgroup analyses revealed that such trend was consistent in the third-trimester (SMD: 1.35; 95% CI: 0.72–1.98), Turkish (SMD: 0.81; 95% CI: 0.43–1.19), and Italian (SMD: 2.78; 95% CI: 2.22–3.34) patients with GDM and the patients diagnosed based on Carpenter and Coustan criteria (SMD: 1.04; 95% CI: 0.42–1.65). Significantly higher MPV also were observed within cross-sectional studies (SMD: 0.99; 95% CI: 0.49–1.49). Remarkable between-study heterogeneity and potential publication bias were observed in this meta-analysis; however, sensitivity analysis indicated that the results were not unduly influenced by any single study. Conclusions. GDM patients are accompanied by increased MPV, strengthening the clinical evidence that MPV may be a predictive marker for GDM.http://dx.doi.org/10.1155/2018/1985026 |
| spellingShingle | Zhongwei Zhou Hongmei Chen Mingzhong Sun Huixiang Ju Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis Journal of Diabetes Research |
| title | Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full | Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_fullStr | Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_short | Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_sort | mean platelet volume and gestational diabetes mellitus a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2018/1985026 |
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