GPx-mimetic selenium-enriched yeast nanozymes ameliorate diabetic bone disease via dual-targeting of ROS scavenging and angiogenesis-osteogenesis coupling

GPx-mimetic selenium-enriched yeast nanozymes ameliorate diabetic bone disease via dual-targeting of ROS scavenging and angiogenesis-osteogenesis coupling

Diabetic bone disease (DBD) is a severe skeletal complication arising from metabolic dysregulation and redox imbalance during diabetes progression. Its core pathological mechanism involves reactive oxygen species (ROS)-mediated decoupling of angiogenesis-osteogenesis, yet no targeted therapies exist...

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Bibliographic Details
Main Authors: Zimei Wu, Qiaodan Hou, Lang Qin, Tingting Chen, Kunkun Yang, Fuxin Wei, Lin Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Diabetic bone disease (DBD)
Selenium-enriched yeast
Nanozymes
Oxidative stress
Angiogenesis-osteogenesis coupling
Type H vessels
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425003965
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