Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds
Restorative and endodontic procedures have been recently developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli, such as caries infection or traumatic injury. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible da...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/190561 |
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| _version_ | 1832548685981941760 |
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| author | Chiaki Kitamura Tatsuji Nishihara Masamichi Terashita Yasuhiko Tabata Ayako Washio |
| author_facet | Chiaki Kitamura Tatsuji Nishihara Masamichi Terashita Yasuhiko Tabata Ayako Washio |
| author_sort | Chiaki Kitamura |
| collection | DOAJ |
| description | Restorative and endodontic procedures have been recently developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli, such as caries infection or traumatic injury. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Nonvital teeth lose their defensive abilities and become severely damaged, resulting in extraction. Development of regeneration therapy for the dentin-pulp complex is important to overcome limitations with presently available therapies. Three strategies to regenerate the dentin-pulp complex have been proposed; regeneration of the entire tooth, local regeneration of the dentin-pulp complex from amputated dental pulp, and regeneration of dental pulp from apical dental pulp or periapical tissues. In this paper, we focus on the local regeneration of the dentin-pulp complex by application of exogenous growth factors and scaffolds to amputated dental pulp. |
| format | Article |
| id | doaj-art-884055c203aa475a8ff7a0ddc19f8542 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-884055c203aa475a8ff7a0ddc19f85422025-02-03T06:13:22ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/190561190561Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like ScaffoldsChiaki Kitamura0Tatsuji Nishihara1Masamichi Terashita2Yasuhiko Tabata3Ayako Washio4Division of Pulp Biology, Operative Dentistry and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, JapanDivision of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, JapanDivision of Comprehensive Dentistry, Department of Clinical Communication and Practice, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, JapanDepartment of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, JapanDivision of Pulp Biology, Operative Dentistry and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, JapanRestorative and endodontic procedures have been recently developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli, such as caries infection or traumatic injury. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Nonvital teeth lose their defensive abilities and become severely damaged, resulting in extraction. Development of regeneration therapy for the dentin-pulp complex is important to overcome limitations with presently available therapies. Three strategies to regenerate the dentin-pulp complex have been proposed; regeneration of the entire tooth, local regeneration of the dentin-pulp complex from amputated dental pulp, and regeneration of dental pulp from apical dental pulp or periapical tissues. In this paper, we focus on the local regeneration of the dentin-pulp complex by application of exogenous growth factors and scaffolds to amputated dental pulp.http://dx.doi.org/10.1155/2012/190561 |
| spellingShingle | Chiaki Kitamura Tatsuji Nishihara Masamichi Terashita Yasuhiko Tabata Ayako Washio Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds International Journal of Dentistry |
| title | Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds |
| title_full | Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds |
| title_fullStr | Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds |
| title_full_unstemmed | Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds |
| title_short | Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds |
| title_sort | local regeneration of dentin pulp complex using controlled release of fgf 2 and naturally derived sponge like scaffolds |
| url | http://dx.doi.org/10.1155/2012/190561 |
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