Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy
Chemotherapeutic agents result in the loss of growing follicles, which can manifest as amenorrhoea. Alkylating chemotherapy (AC) is known to be more gonadotoxic than non-alkylating chemotherapy (NAC). Anti-Müllerian hormone (AMH), an indirect marker of ovarian reserve, and age have been investigated...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2025-01-01
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| Series: | Reproduction and Fertility |
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| Online Access: | https://raf.bioscientifica.com/view/journals/raf/6/1/RAF-24-0046.xml |
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| author | Madhavi-Priya Singh Rashi Kalra Franca Agresta Alec Leos Samith Minu Alwis Alex Polyakov Genia Rozen Kate Stern |
| author_facet | Madhavi-Priya Singh Rashi Kalra Franca Agresta Alec Leos Samith Minu Alwis Alex Polyakov Genia Rozen Kate Stern |
| author_sort | Madhavi-Priya Singh |
| collection | DOAJ |
| description | Chemotherapeutic agents result in the loss of growing follicles, which can manifest as amenorrhoea. Alkylating chemotherapy (AC) is known to be more gonadotoxic than non-alkylating chemotherapy (NAC). Anti-Müllerian hormone (AMH), an indirect marker of ovarian reserve, and age have been investigated as predictors of ovarian function after chemotherapy; however, little is known about the time to return of menses. This study aimed to assess how patient age and baseline serum AMH levels at cancer diagnosis affect the time to return of menses post-chemotherapy. This retrospective cohort study examined oncology patients (n = 67) who underwent chemotherapy and were treated through the Reproductive Services Unit of two institutions in Melbourne, Australia. Primary outcomes included the correlation between age and baseline AMH with time to return of menses after chemotherapy. Secondary outcomes include the change in AMH levels at 6- and 12-months post-completion of chemotherapy. Pairwise correlation of the pre-chemotherapy AMH level and time to return of menses demonstrated statistical significance (Spearman’s coefficient, ρ = −0.40) for patients who underwent AC. This analysis in breast cancer patients who underwent AC displayed a negative correlation but was not statistically significant. No association was found between age and time to return of menses for all cancer (NAC or AC) or breast cancer patients who underwent AC. Higher AMH levels prior to AC were associated with an earlier return of menses after chemotherapy. Age at the commencement of chemotherapy was not associated with return of menses. Further prospective research is required to assess post-chemotherapy recovery of AMH. |
| format | Article |
| id | doaj-art-88375fe1f8e14652876a1bc657fb91fe |
| institution | Kabale University |
| issn | 2633-8386 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Reproduction and Fertility |
| spelling | doaj-art-88375fe1f8e14652876a1bc657fb91fe2025-01-25T15:01:58ZengBioscientificaReproduction and Fertility2633-83862025-01-016110.1530/RAF-24-00461Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapyMadhavi-Priya Singh0Rashi Kalra1Franca Agresta2Alec Leos3Samith Minu Alwis4Alex Polyakov5Genia Rozen6Kate Stern7Austin Health, Melbourne, Victoria, AustraliaMelbourne IVF, East Melbourne, Victoria, AustraliaMelbourne IVF, East Melbourne, Victoria, AustraliaThe University of Melbourne, Melbourne, Victoria, AustraliaAustin Health, Melbourne, Victoria, AustraliaRoyal Women’s Hospital, Melbourne, Victoria, AustraliaRoyal Women’s Hospital, Melbourne, Victoria, AustraliaMelbourne IVF, East Melbourne, Victoria, AustraliaChemotherapeutic agents result in the loss of growing follicles, which can manifest as amenorrhoea. Alkylating chemotherapy (AC) is known to be more gonadotoxic than non-alkylating chemotherapy (NAC). Anti-Müllerian hormone (AMH), an indirect marker of ovarian reserve, and age have been investigated as predictors of ovarian function after chemotherapy; however, little is known about the time to return of menses. This study aimed to assess how patient age and baseline serum AMH levels at cancer diagnosis affect the time to return of menses post-chemotherapy. This retrospective cohort study examined oncology patients (n = 67) who underwent chemotherapy and were treated through the Reproductive Services Unit of two institutions in Melbourne, Australia. Primary outcomes included the correlation between age and baseline AMH with time to return of menses after chemotherapy. Secondary outcomes include the change in AMH levels at 6- and 12-months post-completion of chemotherapy. Pairwise correlation of the pre-chemotherapy AMH level and time to return of menses demonstrated statistical significance (Spearman’s coefficient, ρ = −0.40) for patients who underwent AC. This analysis in breast cancer patients who underwent AC displayed a negative correlation but was not statistically significant. No association was found between age and time to return of menses for all cancer (NAC or AC) or breast cancer patients who underwent AC. Higher AMH levels prior to AC were associated with an earlier return of menses after chemotherapy. Age at the commencement of chemotherapy was not associated with return of menses. Further prospective research is required to assess post-chemotherapy recovery of AMH.https://raf.bioscientifica.com/view/journals/raf/6/1/RAF-24-0046.xmlanti-müllerian hormonechemotherapyfertilitymensesoncofertility |
| spellingShingle | Madhavi-Priya Singh Rashi Kalra Franca Agresta Alec Leos Samith Minu Alwis Alex Polyakov Genia Rozen Kate Stern Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy Reproduction and Fertility anti-müllerian hormone chemotherapy fertility menses oncofertility |
| title | Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy |
| title_full | Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy |
| title_fullStr | Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy |
| title_full_unstemmed | Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy |
| title_short | Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy |
| title_sort | age and serum anti mullerian hormone levels as predictors of time to return of menses after chemotherapy |
| topic | anti-müllerian hormone chemotherapy fertility menses oncofertility |
| url | https://raf.bioscientifica.com/view/journals/raf/6/1/RAF-24-0046.xml |
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