The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients
Background Cardiovascular disease (CVD) is a major complication in peritoneal dialysis (PD) patients. Previous studies have demonstrated that platelet distribution width (PDW) is associated with cardiovascular events in hemodialysis (HD) patients. In this study, we hypothesized that elevated PDW can...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300730 |
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| author | Chunyu Lu Shuiqin Cheng Wenjing Fan Zhihong Zhang Jinquan Wang |
| author_facet | Chunyu Lu Shuiqin Cheng Wenjing Fan Zhihong Zhang Jinquan Wang |
| author_sort | Chunyu Lu |
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| description | Background Cardiovascular disease (CVD) is a major complication in peritoneal dialysis (PD) patients. Previous studies have demonstrated that platelet distribution width (PDW) is associated with cardiovascular events in hemodialysis (HD) patients. In this study, we hypothesized that elevated PDW can predict all-cause and cardiovascular mortality in PD patients.Methods We recruited PD patients for a single-center retrospective cohort study from 1 January 2007, to 30 June 2020. Receiver-operating characteristic (ROC) curves were made to determine the PDW cutoff value for predicting all-cause mortality. The propensity score matching (PSM) method was used to improve the equilibrium between groups. The relation of PDW with all-cause and cardiovascular mortality was analyzed by Cox proportional hazards models. Restricted cubic spline (RCS) models were used to determine whether there was a linear relationship between PDW and all-cause and cardiovascular mortality.Results A total of 720 PD patients were screened, and 426 PD patients were enrolled after PSM. After adjusting for confounders, Cox proportional hazards models showed that the PDW value was positively correlated with the risk of all-cause and cardiovascular mortality (HR = 1.162, 95% CI 1.057–1.278, p = 0.002 and HR = 1.200, 95% CI 1.041–1.382, p = 0.012). The adjusted RCS analysis further showed that the relationship of PDW with all-cause and cardiovascular mortality was linear (p for nonlinearly = 0.143 and 0.062).Conclusion Elevated PDW is independently associated with all-cause and cardiovascular mortality in PD patients. |
| format | Article |
| id | doaj-art-882712db38a84e4f89950f5247b4206f |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-882712db38a84e4f89950f5247b4206f2025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2300730The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patientsChunyu Lu0Shuiqin Cheng1Wenjing Fan2Zhihong Zhang3Jinquan Wang4Jinling Hospital Department of Nephrology, Nanjing Medical University, Nanjing, PR ChinaNational Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR ChinaNational Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR ChinaNational Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR ChinaJinling Hospital Department of Nephrology, Nanjing Medical University, Nanjing, PR ChinaBackground Cardiovascular disease (CVD) is a major complication in peritoneal dialysis (PD) patients. Previous studies have demonstrated that platelet distribution width (PDW) is associated with cardiovascular events in hemodialysis (HD) patients. In this study, we hypothesized that elevated PDW can predict all-cause and cardiovascular mortality in PD patients.Methods We recruited PD patients for a single-center retrospective cohort study from 1 January 2007, to 30 June 2020. Receiver-operating characteristic (ROC) curves were made to determine the PDW cutoff value for predicting all-cause mortality. The propensity score matching (PSM) method was used to improve the equilibrium between groups. The relation of PDW with all-cause and cardiovascular mortality was analyzed by Cox proportional hazards models. Restricted cubic spline (RCS) models were used to determine whether there was a linear relationship between PDW and all-cause and cardiovascular mortality.Results A total of 720 PD patients were screened, and 426 PD patients were enrolled after PSM. After adjusting for confounders, Cox proportional hazards models showed that the PDW value was positively correlated with the risk of all-cause and cardiovascular mortality (HR = 1.162, 95% CI 1.057–1.278, p = 0.002 and HR = 1.200, 95% CI 1.041–1.382, p = 0.012). The adjusted RCS analysis further showed that the relationship of PDW with all-cause and cardiovascular mortality was linear (p for nonlinearly = 0.143 and 0.062).Conclusion Elevated PDW is independently associated with all-cause and cardiovascular mortality in PD patients.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300730Platelet distribution widthperitoneal dialysisall-cause mortalitycardiovascular mortalitypropensity score matching |
| spellingShingle | Chunyu Lu Shuiqin Cheng Wenjing Fan Zhihong Zhang Jinquan Wang The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients Renal Failure Platelet distribution width peritoneal dialysis all-cause mortality cardiovascular mortality propensity score matching |
| title | The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients |
| title_full | The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients |
| title_fullStr | The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients |
| title_full_unstemmed | The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients |
| title_short | The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients |
| title_sort | relationship of platelet distribution width with all cause and cardiovascular mortality in peritoneal dialysis patients |
| topic | Platelet distribution width peritoneal dialysis all-cause mortality cardiovascular mortality propensity score matching |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300730 |
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